BRCA2

BRCA2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1N0W, 3EU7
Dynodwyr
Cyfenwau	BRCA2, BRCC2, BROVCA2, FACD, FAD, FAD1, FANCD, FANCD1, GLM3, PNCA2, XRCC11, breast cancer 2, DNA repair associated, breast cancer 2, early onset, BRCA2 DNA repair associated, Genes
Dynodwyr allanol	OMIM: 600185 HomoloGene: 41 GeneCards: BRCA2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • H4 histone acetyltransferase activity • H3 histone acetyltransferase activity • protease binding • histone acetyltransferase activity • GO:0001948, GO:0016582 protein binding • gamma-tubulin binding • single-stranded DNA binding • protein C-terminus binding • identical protein binding Cydrannau o'r gell • centrosome • BRCA2-MAGE-D1 complex • secretory granule • nucleoplasm • microtubule organizing center • cnewyllyn cell • Cytosgerbwd • lateral element • cytoplasm • cytosol • GO:0009327 protein-containing complex Prosesau biolegol • chordate embryonic development • nucleotide-excision repair • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator • DNA recombination • regulation of cytokinesis • replication fork protection • centrosome duplication • male meiosis I • negative regulation of mammary gland epithelial cell proliferation • positive regulation of mitotic cell cycle • GO:0051312, GO:0007083 chromosome organization • female gonad development • inner cell mass cell proliferation • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • telomere maintenance via recombination • brain development • oocyte maturation • histone H3 acetylation • spermatogenesis • intrinsic apoptotic signaling pathway in response to DNA damage • establishment of protein localization to telomere • histone H4 acetylation • cellular response to DNA damage stimulus • cell cycle • cell population proliferation • response to gamma radiation • response to UV-C • response to X-ray • DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator • GO:1903211 mitotic recombination-dependent replication fork processing • double-strand break repair via homologous recombination • GO:0100026 DNA repair • double-strand break repair • mitotic cytokinesis • hemopoiesis • response to nutrient • meiotic DNA repair synthesis involved in reciprocal meiotic recombination • mammary gland development • homologous chromosome orientation involved in meiotic metaphase I plate congression • response to estradiol • multicellular organism growth • DNA synthesis involved in double-strand break repair via homologous recombination • meiotic recombination checkpoint signaling Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	675	n/a
Ensembl	ENSG00000139618	n/a
UniProt	P51587	n/a
RefSeq (mRNA)	NM_000059	n/a
RefSeq (protein)	NP_000050	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn BRCA2 yw BRCA2 a elwir hefyd yn BRCA2, DNA repair associated (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 13, band 13q13.1.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn BRCA2.

• "BRCA2 suppresses replication stress-induced mitotic and G1 abnormalities through homologous recombination. ". Nat Commun. 2017. PMID 28904335.
• "Monoallelic characteristic-bearing heterozygous L1053X in BRCA2 gene among Sudanese women with breast cancer. ". BMC Med Genet. 2017. PMID 28814288.
• "A Class of Environmental and Endogenous Toxins Induces BRCA2 Haploinsufficiency and Genome Instability. ". Cell. 2017. PMID 28575672.
• "Modulation of HAT activity by the BRCA2 N372H variation is a novel mechanism of paclitaxel resistance in breast cancer cell lines. ". Biochem Pharmacol. 2017. PMID 28431939.
• "Functional classification of DNA variants by hybrid minigenes: Identification of 30 spliceogenic variants of BRCA2 exons 17 and 18.". PLoS Genet. 2017. PMID 28339459.