BCL3

BCL3
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1K1A, 1K1B
Dynodwyr
Cyfenwau	BCL3, BCL4, D19S37, B-cell CLL/lymphoma 3, B cell CLL/lymphoma 3, transcription coactivator, BCL3 transcription coactivator
Dynodwyr allanol	OMIM: 109560 HomoloGene: 81738 GeneCards: BCL3
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• DNA binding; • protein-macromolecule adaptor activity; • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • transcription factor binding; • GO:0001948, GO:0016582 protein binding;
Cydrannau o'r gell	• cytoplasm; • Bcl3-Bcl10 complex; • nucleoplasm; • perinuclear region of cytoplasm; • Bcl3/NF-kappaB2 complex; • cnewyllyn cell; • cytosol; • cellbilen; • midbody; • intracellular membrane-bounded organelle; • GO:0009327 protein-containing complex;
Prosesau biolegol	• regulation of apoptotic process; • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; • regulation of DNA binding; • GO:0009373 regulation of transcription, DNA-templated; • T-helper 2 cell differentiation; • antimicrobial humoral response; • germinal center formation; • response to virus; • DNA damage response, signal transduction by p53 class mediator; • extracellular matrix organization; • positive regulation of interferon-gamma production; • negative regulation of apoptotic process; • spleen development; • marginal zone B cell differentiation; • positive regulation of translation; • transcription, DNA-templated; • cellular response to DNA damage stimulus; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • humoral immune response mediated by circulating immunoglobulin; • follicular dendritic cell differentiation; • defense response to bacterium; • T-helper 1 type immune response; • GO:0045996 negative regulation of transcription, DNA-templated; • I-kappaB kinase/NF-kappaB signaling; • response to UV-C; • maintenance of protein location in nucleus; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • defense response to protozoan; • negative regulation of receptor signaling pathway via JAK-STAT; • regulation of NIK/NF-kappaB signaling;
	Sources:Amigo / QuickGO
Orthologau
	602
	n/a
	ENSG00000069399
	n/a
	P20749
	n/a
	NM_005178
	n/a
	NP_005169
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn BCL3 yw BCL3 a elwir hefyd yn B-cell CLL/lymphoma 3 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 19, band 19q13.32.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn BCL3.

BCL4
D19S37

Llyfryddiaeth

"B-cell CLL/lymphoma 3 promotes glioma cell proliferation and inhibits apoptosis through the oncogenic STAT3 pathway. ". Int J Oncol. 2016. PMID 27748795.
"Role of Bcl-3 in the development of follicular helper T cells and in the pathogenesis of rheumatoid arthritis. ". Arthritis Rheumatol. 2015. PMID 26138292.
"Variant of BCL3 gene is strongly associated with five-year survival of non-small-cell lung cancer patients. ". Lung Cancer. 2015. PMID 26122346.
"BCL-3 expression promotes colorectal tumorigenesis through activation of AKT signalling. ". Gut. 2016. PMID 26033966.
"Early diagnostic value of Bcl-3 localization in colorectal cancer.". BMC Cancer. 2015. PMID 25929479.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] BCL3 - Cronfa NCBI

[1]

[2]

BCL3

Cyfystyron

Llyfryddiaeth

Cyfeiriadau

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