ATG4A

ATG4A
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2P82
Dynodwyr
Cyfenwau	ATG4A, APG4A, AUTL2, autophagy related 4A cysteine peptidase, HsAPG4A
Dynodwyr allanol	OMIM: 300663 HomoloGene: 70873 GeneCards: ATG4A
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0070122 peptidase activity • cysteine-type peptidase activity • GO:0001948, GO:0016582 protein binding • hydrolase activity • cysteine-type endopeptidase activity Cydrannau o'r gell • cytoplasm • cytosol Prosesau biolegol • autophagy • protein transport • autophagy of nucleus • C-terminal protein lipidation • protein delipidation • autophagy of mitochondrion • autophagosome assembly • proteolysis • protein targeting to membrane Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	115201	n/a
Ensembl	ENSG00000101844	n/a
UniProt	Q8WYN0	n/a
RefSeq (mRNA)	NM_052936 NM_178270 NM_178271 NM_001321287 NM_001321288 NM_001321289 NM_001321290	n/a
RefSeq (protein)	NP_001308216 NP_001308217 NP_001308218 NP_001308219 NP_443168 NP_840054 NP_840055	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ATG4A yw ATG4A a elwir hefyd yn Autophagy related 4A cysteine peptidase (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom X dynol, band Xq22.3.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ATG4A.

• APG4A
• AUTL2

• "Hypomethylation signature of tumor-initiating cells predicts poor prognosis of ovarian cancer patients. ". Hum Mol Genet. 2014. PMID 24256813.
• "Granulomas in Crohn's disease: are newly discovered genetic variants involved?". J Crohns Colitis. 2010. PMID 21122541.
• "A mammosphere formation RNAi screen reveals that ATG4A promotes a breast cancer stem-like phenotype. ". Breast Cancer Res. 2013. PMID 24229464.
• "A systematic bioinformatics approach for selection of target and screening of ligand for malignant tumours suppressing APG4A gene on Xq22.1. ". Int J Comput Biol Drug Des. 2010. PMID 21297227.
• "Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4.". EMBO J. 2007. PMID 17347651.