AIF1

AIF1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2D58, 2G2B
Dynodwyr
Cyfenwau	AIF1, AIF-1, IBA1, IRT-1, IRT1, allograft inflammatory factor 1, Iba-1
Dynodwyr allanol	OMIM: 601833 HomoloGene: 1226 GeneCards: AIF1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • calcium ion binding • metal ion binding • actin filament binding • actin binding • molecular function Cydrannau o'r gell • cytoplasm • cytosol • perikaryon • cell projection • bilen • ruffle • cellbilen • ruffle membrane • Microffilament • perinuclear region of cytoplasm • phagocytic cup • Cytosgerbwd • cnewyllyn cell • lamellipodium Prosesau biolegol • cellular response to extracellular stimulus • positive regulation of smooth muscle cell chemotaxis • response to cytokine • positive regulation of protein phosphorylation • negative regulation of smooth muscle cell proliferation • positive regulation of cell migration • positive regulation of muscle hyperplasia • positive regulation of nitric oxide biosynthetic process • positive regulation of monocyte chemotaxis • negative regulation of apoptotic process • response to glucocorticoid • response to electrical stimulus • negative regulation of gene expression • cellular response to hydroperoxide • actin filament bundle assembly • microglial cell activation • positive regulation of G1/S transition of mitotic cell cycle • actin filament polymerization • negative regulation of smooth muscle cell chemotaxis • cellular response to hormone stimulus • phagocytosis, engulfment • response to axon injury • positive regulation of T cell proliferation • cellular response to interferon-gamma • cellular response to morphine • Rac protein signal transduction • inflammatory response • ruffle assembly • positive regulation of T cell migration • positive regulation of smooth muscle cell proliferation • cerebellum development • positive regulation of cell population proliferation • regulation of gene expression • parallel actin filament bundle assembly • cellular response to oxidative stress • positive regulation of chemotaxis • actin crosslink formation • positive regulation of mononuclear cell migration • positive regulation of fibroblast growth factor production Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	199	n/a
Ensembl	ENSG00000206428 ENSG00000235985 ENSG00000235588 ENSG00000234836 ENSG00000237727 ENSG00000204472	n/a
UniProt	P55008 Q4V347	n/a
RefSeq (mRNA)	NM_001623 NM_004847 NM_032955 NM_001318970	n/a
RefSeq (protein)	NP_001305899 NP_001614 NP_116573 NP_001614.3	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn AIF1 yw AIF1 a elwir hefyd yn Allograft inflammatory factor 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 6, band 6p21.33.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn AIF1.

• "Expression of allograft inflammatory factor-1 in peripheral blood monocytes and synovial membranes in patients with rheumatoid arthritis. ". Hum Immunol. 2016. PMID 26585362.
• "Influence of AIF1 Gene Polymorphisms on Long-Term Kidney Allograft Function. ". Ann Transplant. 2015. PMID 26324213.
• "[Association between AIF-1 gene polymorphisms and response to rheumatoid arthritis treatment with sulphasalazine]. ". Ann Acad Med Stetin. 2013. PMID 25026748.
• "Allograft inflammatory factor-1 stimulates chemokine production and induces chemotaxis in human peripheral blood mononuclear cells. ". Biochem Biophys Res Commun. 2014. PMID 24796669.
• "Allograft inflammatory factor-1 is an independent prognostic indicator that regulates β-catenin in gastric cancer.". Oncol Rep. 2014. PMID 24337893.