PKIG

PKIG
Identifikatori
Aliasi	PKIG
Vanjski ID-jevi	OMIM: 604932 MGI: 1343086 HomoloGene: 5133 GeneCards: PKIG
Lokacija gena (čovjek) Hrom. Hromosom 20 (čovjek)[1] Bend 20q13.12 Početak 44,531,785 bp[1] Kraj 44,624,247 bp[1]
Lokacija gena (miš) Hrom. Hromosom 2 (miš)[2] Bend 2 H3|2 84.4 cM Početak 163,500,306 bp[2] Kraj 163,568,078 bp[2]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • protein kinase inhibitor activity • cAMP-dependent protein kinase inhibitor activity Ćelijska komponenta • citoplazma • jedro Biološki proces • GO:1901227 negative regulation of transcription by RNA polymerase II • negative regulation of cAMP-dependent protein kinase activity • GO:0072468 Transdukcija signala • negative regulation of protein kinase activity • negative regulation of protein import into nucleus Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	11142	18769
Ensembl	ENSG00000168734	ENSMUSG00000035268
UniProt	Q9Y2B9	O70139
RefSeq (mRNK)	NM_181805 NM_001281444 NM_001281445 NM_007066 NM_181804	NM_001039390 NM_001039391 NM_001164053 NM_001164055 NM_001277096 NM_011106
RefSeq (bjelančevina)	NP_001268373 NP_001268374 NP_008997 NP_861520 NP_861521	NP_001034479 NP_001034480 NP_001157525 NP_001157527 NP_001264025 NP_035236
Lokacija (UCSC)	Chr 20: 44.53 – 44.62 Mb	Chr 2: 163.5 – 163.57 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Gama inhibitor cAMP-ovisne proteina-kinaze je protein kiji je kod ljudi kodiran genom PKIG.^[5][6]

Protein kodiran ovim genom član je porodice inhibitora ovisne o cAMP protein-kinazama (PKA). Studije sličnih proteina na miševima sugeriraju da ovaj protein djeluje kao snažni kompetitivni inhibitor PKA i da je prevladavajući oblik inhibitora PKA u različitim tkivima. Prijavljene su tri alternativno prerađene varijante transkripta koji kodiraju isti protein.^[6]

Reference

1. GRCh38: Ensembl release 89: ENSG00000168734 - Ensembl, maj 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000035268 - Ensembl, maj 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Zheng L, Yu L, Tu Q, Zhang M, He H, Chen W, Gao J, Yu J, Wu Q, Zhao S (Jan 2001). "Cloning and mapping of human PKIB and PKIG, and comparison of tissue expression patterns of three members of the protein kinase inhibitor family, including PKIA". Biochem J. 349 (Pt 2): 403–7. doi:10.1042/0264-6021:3490403. PMC 1221161. PMID 10880337.
6. "Entrez Gene: PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma".

Dopunska literatura

• Collins SP, Uhler MD (1997). "Characterization of PKIgamma, a novel isoform of the protein kinase inhibitor of cAMP-dependent protein kinase". J. Biol. Chem. 272 (29): 18169–78. doi:10.1074/jbc.272.29.18169. PMID 9218452.
• Fossey SC, Mychaleckyj JC, Pendleton JK, et al. (2001). "A high-resolution 6.0-megabase transcript map of the type 2 diabetes susceptibility region on human chromosome 20". Genomics. 76 (1–3): 45–57. doi:10.1006/geno.2001.6584. PMID 11549316.
• Lum H, Hao Z, Gayle D, et al. (2002). "Vascular endothelial cells express isoforms of protein kinase A inhibitor". Am. J. Physiol., Cell Physiol. 282 (1): C59–66. doi:10.1152/ajpcell.00256.2001. PMID 11742798.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
• Yu J, Yu L, Chen Z, et al. (2002). "Protein inhibitor of neuronal nitric oxide synthase interacts with protein kinase A inhibitors". Brain Res. Mol. Brain Res. 99 (2): 145–9. doi:10.1016/S0169-328X(02)00104-3. PMID 11978406.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Zhao L, Yang S, Zhou GQ, et al. (2006). "Downregulation of cAMP-dependent protein kinase inhibitor gamma is required for BMP-2-induced osteoblastic differentiation". Int. J. Biochem. Cell Biol. 38 (12): 2064–73. doi:10.1016/j.biocel.2006.05.015. PMID 16870489.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.