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Thomas Spence (1750–1814) was an English Radical. Other notable people with the same name include:

Thomas Ara Spence (1810–1877), American politician
Thomas Wilson Spence (1846–1912), Irish-American lawyer and politician
Thomas Ralph Spence (c. 1855–1918), English painter, sculptor and architect

This disambiguation page lists articles about people with the same name.
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Thomas Spence (disambiguation)