Two Professors find an ancient vase at a shop on the docks. They track down Dick Nelson (Richard Talmadge), the sailor who sold it after finding it on an island where he was shipwrecked as a boy.
Professors Sneed (Henry Roquemore) and Harris (Jimmy Aubrey) charter a ship to have Dick guide them to find more ancient treasures on this uncharted island; but they do not want Captain King (Charles K. French) to bring his daughter Madge (Alberta Vaughn), who usually sails with him, saying it will be too dangerous for a woman to go with them.
Sam the Cook (Sam McDaniel) helps Madge stow away aboard the ship. When she is found she pretends to be a boy, just hired on as a steward.
Dick’s old nemesis “Bull” Dennis (George Walsh) has been hired on to replace the First Mate. Like Long John Silver, Bull plans a mutiny so he can keep all the treasure for himself and his pirate comrades.
It looks like Dick and Madge, with the help of Sam and the others, are going to foil the mutineer’s plan; but the ship is lost in a fire, and, unbeknownst to each other, they all end up shipwrecked on the mysterious island.
At first Bill can’t remember where the ruins are, but he soon finds an entire lost city and civilization. Soon, however, they are fighting for their lives with the pirates to get off the island alive.[4]