In the 1790s, the original town site of the Town of York was established along its south bank. Its waters would be used by its first industries. The disappearance of the creek came in phases in the 19th century:
east of Church Street - before 1860
Elizabeth Street to Church Street - early 1866
University of Toronto sections including McCaul's Pond - 1886
There is no exact origin for the creek's name but there are three possible theories:[3]
named for the Tattle family of Toronto
named for the tadpoles that filled the creek
onomatopoeic link of an English northcountry dialect variant of toddle meaning "to move with a gentle sound, as a stream or river"
Taddle Creek had other names during the 19th Century:
Little Don River
Brewery Creek - named for Enoch Turner's brewery
Goodwin Creek
University Creek
Wolz Creek - east of Jarvis after brewer John Wolz (or Walz)