TRIL (gene)

TRIL
Identifiers
Aliases	TRIL, KIAA0644, TLR4 interactor with leucine rich repeats
External IDs	OMIM: 613356; MGI: 1914123; HomoloGene: 69404; GeneCards: TRIL; OMA:TRIL - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7p14.3 Start 28,953,358 bp[1] End 28,958,330 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 B3 Start 53,792,453 bp[2] End 53,797,815 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in internal globus pallidus external globus pallidus dorsal motor nucleus of vagus nerve pars compacta pars reticulata caudate nucleus putamen Region I of hippocampus proper Amygdala nucleus accumbens Top expressed in Gonadal ridge vestibular sensory epithelium utricle vas deferens renal corpuscle medullary collecting duct lumbar subsegment of spinal cord maxillary prominence limb bud mandibular prominence More reference expression data BioGPS n/a
Gene ontology Molecular function lipopolysaccharide binding Cellular component integral component of membrane lipopolysaccharide receptor complex membrane extracellular space extracellular matrix Biological process regulation of cytokine production involved in immune response innate immune response inflammatory response toll-like receptor 4 signaling pathway immune system process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9865 66873 Ensembl ENSG00000255690 ENSMUSG00000043496 UniProt Q7L0X0 Q9DBY4 RefSeq (mRNA) NM_014817 NM_025817 RefSeq (protein) NP_055632 NP_080093 Location (UCSC) Chr 7: 28.95 – 28.96 Mb Chr 6: 53.79 – 53.8 Mb PubMed search [3] [4]
Wikidata
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KIAA0644, also known as TRIL or TLR4 interactor with leucine rich repeats, is a protein that in humans is encoded by the KIAA0644 gene.^[5]

Function

The exact function of KIAA0644 is not known. It is, however, a member of the leucine-rich repeat family of proteins, which are known to be involved in protein-protein interactions. This protein is known to interact with the TLR4 protein.

TRIL is a component of the TLR4 complex and is induced in a number of cell types by lipopolysaccharide (LPS).^[6]

Protein sequence

The main isoform of the human protein is 811 amino long and is composed primarily of leucine (17%), alanine and arginine (~10%), and glycine (~ 8.5%) residues. The protein sequence is predicted to consists mostly of α-helices and a few β-sheet

Homology

KIAA0644 is conserved well among mammals but can be found in all chordates with lower sequence identities.

Gene neighborhood

The KIAA0644 gene is neighbors to mRNA-cAMP responsive element binding gene downstream and mRNA carboxypeptidase and serine carboxypeptidase gene upstream ^[7][8]

References

1. GRCh38: Ensembl release 89: ENSG00000255690 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000043496 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: TRIL TLR4 interactor with leucine rich repeats". Retrieved 13 May 2010.
6. Carpenter S, Carlson T, Dellacasagrande J, Garcia A, Gibbons S, Hertzog P, Lyons A, Lin LL, Lynch M, Monie T, Murphy C, Seidl KJ, Wells C, Dunne A, O'Neill LA (September 2009). "TRIL, a functional component of the TLR4 signaling complex, highly expressed in brain". J. Immunol. 183 (6): 3989–3995. doi:10.4049/jimmunol.0901518. PMID 19710467.
7. "NCBI Entrez". Retrieved 13 May 2010.
8. Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (June 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro" (PDF). DNA Res. 5 (3): 169–176. doi:10.1093/dnares/5.3.169. PMID 9734811.

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human Chromosome 7: DNA Sequence and Biology". Science. 300 (5620): 767–772. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
• Büssow K, Cahill D, Nietfeld W, et al. (1998). "A method for global protein expression and antibody screening on high-density filters of an arrayed cDNA library". Nucleic Acids Res. 26 (21): 5007–5008. doi:10.1093/nar/26.21.5007. PMC 147919. PMID 9776767.
• Wheeler HE, Metter EJ, Tanaka T, et al. (2009). Gibson G (ed.). "Sequential Use of Transcriptional Profiling, Expression Quantitative Trait Mapping, and Gene Association Implicates MMP20 in Human Kidney Aging". PLOS Genet. 5 (10): e1000685. doi:10.1371/journal.pgen.1000685. PMC 2752811. PMID 19834535.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.