Sodium calcium edetate

This article is about the medication. For the chemical, see Ethylenediaminetetraacetic acid.

Sodium calcium edetate

Clinical data
Trade names	Calcium disodium versenate, others
Other names	calcium disodium EDTA, edetate calcium disodium, sodium calcium edetate
AHFS/Drugs.com	Monograph
Routes of administration	IV, IM
Drug class	chelating agent
ATC code	V03AB03 (WHO)
Legal status
Legal status	US: WARNING[1]
Identifiers
IUPAC name Calcium disodium 2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate
CAS Number	62-33-9
PubChem CID	6093170
DrugBank	DB00974
ChemSpider	5883
UNII	8U5D034955
ChEBI	CHEBI:4757
E number	E385 (antioxidants, ...)
CompTox Dashboard (EPA)	DTXSID2036409
ECHA InfoCard	100.000.482
Chemical and physical data
Formula	C10H12CaN2Na2O8
Molar mass	374.270 g·mol^−1
3D model (JSmol)	Interactive image
SMILES C(CN(CC(=O)[O-])CC(=O)[O-])N(CC(=O)[O-])CC(=O)[O-].[Na+].[Na+].[Ca+2]
InChI InChI=1S/C10H16N2O8.Ca.2Na/c13-7(14)3-11(4-8(15)16)1-2-12(5-9(17)18)6-10(19)20;;;/h1-6H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20);;;/q;+2;2*+1/p-4 Key:SHWNNYZBHZIQQV-UHFFFAOYSA-J

Sodium calcium edetate (sodium calcium EDTA), also known as edetate calcium disodium among other names, is a medication primarily used to treat lead poisoning,^[2] including both short-term and long-term lead poisoning.^[3] Sodium calcium edetate came into medical use in the United States in 1953.^[3]

Chelation agent

Sodium calcium edetate is in the chelating agent family of medication.^[3] It is a salt of edetate with two sodium atoms and one calcium atom.^[4] It works by binding to a number of heavy metals, which renders them almost inert and allows them to leave the body in the urine.^[3]

Edetate disodium (Endrate) is a different formulation which does not have the same effects.^[3]

Medical use

Sodium calcium edetate's primary use is to treat lead poisoning,^[2] for which it is an alternative to succimer.^[3] It is given by slow injection into a vein or into a muscle.^[2]

For lead encephalopathy sodium calcium edetate is typically used together with dimercaprol.^[3] It may also be used to treat plutonium poisoning.^[5] It does not appear to be useful for poisoning by tetra-ethyl lead.^[3]

Side effects

Common side effects include pain at the site of injection.^[3] Other side effects may include kidney problems, diarrhea, fever, muscle pains, and low blood pressure.^[2] Benefits when needed in pregnancy are likely greater than the risks.^[3]

History

Sodium calcium edetate came into medical use in the United States in 1953.^[3] It is on the World Health Organization's List of Essential Medicines.^[6]

References

1. "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 October 2023.
2. Stuart MC, Kouimtzi M, Hill SR, eds. (2009). WHO Model Formulary 2008. World Health Organization. pp. 59, 62, 65. hdl:10665/44053. ISBN 9789241547659.
3. "Edetate Calcium Disodium". The American Society of Health-System Pharmacists. Archived from the original on 16 January 2017. Retrieved 8 January 2017.
4. Kasture AV (2008). Pharmaceutical Chemistry. Vol. I. Pragati Books Pvt. Ltd. p. 16.11. ISBN 9788185790121. Archived from the original on 16 January 2017.
5. Flanagan R, Jones A, Maynard RL (2003). Antidotes: Principles and Clinical Applications. CRC Press. p. 47. ISBN 9780203485071. Archived from the original on 16 January 2017.
6. Organization WH (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva,CH: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.