She began playing handball at an early age in 1997 at the T.M.O. SK in Ankara. During her university years, İskenderoğlu was a member of the Anadolu University SK between 2003 and 2006. Then, the German club 1. FC Nürnberg transferred her for one season in 2006–2007. After returning home, she played for Üsküdar Bld. SK in Istanbul before she transferred to İzmir Büyükşehir Belediyespor. Three seasons later in 2011–2012, she joined the Muratpaşa Bld. SK in Antalya.[2] In July 2015, she was transferred by Kastamonu Bld. GSK for the 2015–16 season.[3]