Sercloremine

Sercloremine
Names
Preferred IUPAC name
4-(5-Chloro-1-benzofuran-2-yl)-1-methylpiperidine
Identifiers
3D model (JSmol)
ChemSpider
UNII
  • InChI=1S/C14H16ClNO/c1-16-6-4-10(5-7-16)14-9-11-8-12(15)2-3-13(11)17-14/h2-3,8-10H,4-7H2,1H3
    Key: FTKTZRKAVSDSRA-UHFFFAOYSA-N
  • CN1CCC(CC1)C2=CC3=C(O2)C=CC(=C3)Cl
Properties
C14H16ClNO
Molar mass 249.74 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Sercloremine (CGP-4718A), usually as the hydrochloride salt, is a drug which was developed in the 1980s and was formerly under investigation as an antidepressant, but was never marketed.[1][2] It acts as a selective, reversible inhibitor of monoamine oxidase A (RIMA) and serotonin reuptake inhibitor.[1][3]

References

  1. ^ a b Luttinger D, Hlasta DJ (January 1987). "Antidepressant agents". In Hesp B, Bailey DM (eds.). Annual Reports in Medicinal Chemistry. Vol. 22. Academic Press. pp. 21–30 (25). ISBN 978-0-08-058366-2.
  2. ^ Ganellin CR, Triggle DJ (21 November 1996). Dictionary of Pharmacological Agents. CRC Press. pp. 1801–. ISBN 978-0-412-46630-4.
  3. ^ Delini-Stula A, Fischbach R, Gnirss F, Bures E, Pöldinger W (1985). "Early experience with CGP 4718 A (Sercloremine), a new selective and reversible MAO-A and 5-HT-uptake inhibitor, in the treatment of depressive patients". Drug Development Research. 6 (4): 371–384. doi:10.1002/ddr.430060409. ISSN 0272-4391. S2CID 85113482.


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