Vegesna initially worked as a writer and became a director. In 1999, he started working with director Muppalaneni Shiva for a few films like Speed Dancer and Priya O Priya. He worked with E. V. V. Satyanarayana for the film Thotti Gang.[3] This along with Kabaddi Kabaddi gave him a break as a writer. Later he worked with Allari Naresh for several films.
Dongala Bandi was his first film as a director starring Allari Naresh. But this film did not do well at the box office. He worked for director Harish Shankar for the films Gabbar Singh, Ramayya Vastavayya, and Subrahmanyam for Sale. After that he approached producer Dil Raju with the story of Shatamanam Bhavati which became a hit at the box office also garnering a National award and state Nandi award. The film received the National Film Award for Best Popular Film Providing Wholesome Entertainment for "in appreciation of providing a feeling of jubilation by respecting family values in an unexplored manner".[6]