Prentiss was elected in 1831 to the United States Senate as a National Republican. He was reelected as a Whig in 1837 and served from March 4, 1831, to April 11, 1842, when he resigned to accept a judicial appointment.[6] He was Chairman of the Committee on Patents and the Patent Office for the 27th United States Congress.[6]
Anti-dueling statute
While in the Senate, Prentiss was the originator and successful advocate of the law to suppress dueling in the District of Columbia.[1]
Their father, Dr. Samuel Prentiss was a prominent physician and served as a combat surgeon for his father, Colonel Samuel Prentice II, during the American Revolutionary War. The Prentiss family were descendants of Captain Thomas Prentice, who emigrated from England to the Massachusetts Bay Colony in the 1640s and served as a captain during King Philip's War.[8]
Samuel Prentiss IV married Lucretia Houghton (1786–1855), of Northfield, in 1804. They had twelve children, though at least two died in infancy. Their 8th child, Theodore Prentiss, moved to Wisconsin, became the first mayor of Watertown, Wisconsin, and also served in the Wisconsin State Assembly.[8][9]
Notable law student
Among the lawyers who received their education and training in Prentiss's office was William Upham, who later served in the United States Senate.[10]