Levine was born January 1, 1891, in Łomża, Poland, and was brought to the United States at age three.[3]: 473 [4] He graduated from Harvard University at the age of 20, and received a medical degree from Harvard in 1914. In his final year of medical school, he was chosen to do clinical research at Peter Bent Brigham Hospital in Boston. He served as an associate in medicine there and at the Rockefeller Institute.[5]
In 1916, Levine was one of two young physicians recruited by the Harvard Infantile Paralysis Commission to cope with the caseload of that year's poliomyelitis epidemic. In August 1921, Levine gave advice in the case of Franklin D. Roosevelt's paralytic illness.[6]: 64–68, 327–328 He was the first to diagnose it as polio.[3]: 474
Levine was appointed assistant professor of medicine at Harvard in 1930,[5] and physician at Peter Bent Brigham Hospital in 1940.[4] He was clinical professor of medicine at Harvard from 1948 until his retirement in 1958.[5] He was a consultant in cardiology at Brigham Hospital until his death, and affiliated with six other hospitals in the United States.[7]
Levine was a pioneer in the treatment of coronary thrombosis. He was the second American physician to diagnose the condition, which he detailed in his book, Clinical Heart Disease (1936).[8] He was a noted teacher and trainer of heart specialists including Bernard Lown, and also helped diagnose pernicious anemia.[7]
^Levine, Samuel A. (1958). Clinical Heart Decease (Fifth ed.). Philadelphia and London: W B Saunders Company. Retrieved February 19, 2020 – via Internet Archive.