STEAP2

STEAP2
Identifiers
Aliases	STEAP2, IPCA1, PCANAP1, PUMPCn, STAMP1, STMP, STEAP2 metalloreductase
External IDs	OMIM: 605094; MGI: 1921301; HomoloGene: 17682; GeneCards: STEAP2; OMA:STEAP2 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q21.13 Start 90,167,590 bp[1] End 90,238,137 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 A1 Start 5,714,829 bp[2] End 5,744,578 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pericardium Achilles tendon prostate cardiac muscle tissue of right atrium Brodmann area 23 middle temporal gyrus pancreatic epithelial cell cerebellar vermis superior frontal gyrus cartilage tissue Top expressed in Epithelium of choroid plexus endothelial cell of lymphatic vessel oocyte primary oocyte secondary oocyte lumbar subsegment of spinal cord deep cerebellar nuclei lobe of cerebellum human kidney olfactory epithelium More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transporter activity metal ion binding cupric reductase activity ferric-chelate reductase (NADPH) activity oxidoreductase activity Cellular component integral component of membrane integral component of Golgi membrane cytosol endosome membrane plasma membrane early endosome trans-Golgi network transport vesicle endosome membrane integral component of plasma membrane Biological process endocytosis iron ion homeostasis copper ion import ion transport response to hormone regulated exocytosis Golgi to plasma membrane transport iron ion import across cell outer membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 261729 74051 Ensembl ENSG00000157214 ENSMUSG00000015653 UniProt Q8NFT2 Q8BWB6 RefSeq (mRNA) NM_001040665 NM_001040666 NM_001244944 NM_001244945 NM_001244946 NM_152999 NM_001103156 NM_001103157 NM_001285469 NM_001285470 NM_001285471 NM_028734 RefSeq (protein) NP_001035755 NP_001035756 NP_001231873 NP_001231874 NP_001231875 NP_694544 NP_001096626 NP_001096627 NP_001272398 NP_001272399 NP_001272400 NP_083010 Location (UCSC) Chr 7: 90.17 – 90.24 Mb Chr 5: 5.71 – 5.74 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Metalloreductase STEAP2 is an enzyme that in humans is encoded by the STEAP2 gene.^[5][6][7]

This gene is a member of the STEAP family and encodes a multi-pass membrane protein that localizes to the Golgi complex, the plasma membrane, and the vesicular tubular structures in the cytosol.

A highly similar protein in mouse has both ferri reductase and cupric reductase activity, and stimulates the cellular uptake of both iron and copper in vitro. Increased transcriptional expression of the human gene is associated with prostate cancer progression. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000157214 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000015653 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Walker MG, Volkmuth W, Sprinzak E, Hodgson D, Klingler T (Jan 2000). "Prediction of Gene Function by Genome-Scale Expression Analysis: Prostate Cancer-Associated Genes". Genome Res. 9 (12): 1198–203. doi:10.1101/gr.9.12.1198. PMC 310991. PMID 10613842.
6. Korkmaz KS, Elbi C, Korkmaz CG, Loda M, Hager GL, Saatcioglu F (Sep 2002). "Molecular cloning and characterization of STAMP1, a highly prostate-specific six transmembrane protein that is overexpressed in prostate cancer". J Biol Chem. 277 (39): 36689–96. doi:10.1074/jbc.M202414200. PMID 12095985.
7. "Entrez Gene: STEAP2 six transmembrane epithelial antigen of the prostate 2".

Further reading

• Denoeud F, Kapranov P, Ucla C, et al. (2007). "Prominent use of distal 5′ transcription start sites and discovery of a large number of additional exons in ENCODE regions". Genome Res. 17 (6): 746–59. doi:10.1101/gr.5660607. PMC 1891335. PMID 17567994.
• Ohgami RS, Campagna DR, McDonald A, Fleming MD (2006). "The Steap proteins are metalloreductases". Blood. 108 (4): 1388–94. doi:10.1182/blood-2006-02-003681. PMC 1785011. PMID 16609065.
• Korkmaz CG, Korkmaz KS, Kurys P, et al. (2005). "Molecular cloning and characterization of STAMP2, an androgen-regulated six transmembrane protein that is overexpressed in prostate cancer". Oncogene. 24 (31): 4934–45. doi:10.1038/sj.onc.1208677. PMID 15897894.
• Sanchez-Pulido L, Rojas AM, Valencia A, et al. (2005). "ACRATA: a novel electron transfer domain associated to apoptosis and cancer". BMC Cancer. 4: 98. doi:10.1186/1471-2407-4-98. PMC 546010. PMID 15623366.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Porkka KP, Helenius MA, Visakorpi T (2002). "Cloning and characterization of a novel six-transmembrane protein STEAP2, expressed in normal and malignant prostate". Lab. Invest. 82 (11): 1573–82. doi:10.1097/01.lab.0000038554.26102.c6. PMID 12429817.