SCN2B

SCN2B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5FEB, 5FDY
Identifiers
Aliases	SCN2B, ATFB14, sodium voltage-gated channel beta subunit 2
External IDs	OMIM: 601327; MGI: 106921; HomoloGene: 3373; GeneCards: SCN2B; OMA:SCN2B - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q23.3 Start 118,162,806 bp[1] End 118,176,639 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 A5.2|9 24.84 cM Start 45,029,080 bp[2] End 45,041,368 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in middle temporal gyrus lateral nuclear group of thalamus cerebellar cortex cerebellar hemisphere prefrontal cortex right hemisphere of cerebellum cerebellar vermis superior frontal gyrus primary visual cortex right frontal lobe Top expressed in lobe of cerebellum cerebellar vermis lateral geniculate nucleus olfactory tubercle superior colliculus medial geniculate nucleus habenula lateral septal nucleus lateral hypothalamus medial dorsal nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function voltage-gated sodium channel activity involved in cardiac muscle cell action potential sodium channel regulator activity sodium channel activity voltage-gated sodium channel activity voltage-gated ion channel activity Cellular component integral component of membrane voltage-gated sodium channel complex membrane Biological process chemical synaptic transmission nervous system development cardiac muscle cell action potential involved in contraction sodium ion transport sodium ion transmembrane transport regulation of sodium ion transmembrane transporter activity cardiac muscle contraction regulation of heart rate by cardiac conduction regulation of atrial cardiac muscle cell membrane depolarization membrane depolarization during cardiac muscle cell action potential regulation of ion transmembrane transport ion transport response to pyrethroid Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6327 72821 Ensembl ENSG00000149575 ENSMUSG00000070304 UniProt O60939 Q56A07 RefSeq (mRNA) NM_004588 NM_001014761 RefSeq (protein) NP_004579 NP_001014761 Location (UCSC) Chr 11: 118.16 – 118.18 Mb Chr 9: 45.03 – 45.04 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Sodium channel subunit beta-2 is a protein that in humans is encoded by the SCN2B gene.^[5][6]

See also

• Sodium channel

References

1. GRCh38: Ensembl release 89: ENSG00000149575 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000070304 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Plummer NW, Meisler MH (May 1999). "Evolution and diversity of mammalian sodium channel genes". Genomics. 57 (2): 323–31. doi:10.1006/geno.1998.5735. PMID 10198179.
6. "Entrez Gene: SCN2B sodium channel, voltage-gated, type II, beta".

Further reading

• Hartshorne RP, Catterall WA (1984). "The sodium channel from rat brain. Purification and subunit composition". J. Biol. Chem. 259 (3): 1667–75. doi:10.1016/S0021-9258(17)43460-0. PMID 6319405.
• Adams MD, Kerlavage AR, Fleischmann RD, et al. (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF). Nature. 377 (6547 Suppl): 3–174. PMID 7566098.
• Isom LL, Ragsdale DS, De Jongh KS, et al. (1996). "Structure and function of the beta 2 subunit of brain sodium channels, a transmembrane glycoprotein with a CAM motif". Cell. 83 (3): 433–42. doi:10.1016/0092-8674(95)90121-3. PMID 8521473. S2CID 13998841.
• Eubanks J, Srinivasan J, Dinulos MB, et al. (1997). "Structure and chromosomal localization of the beta2 subunit of the human brain sodium channel". NeuroReport. 8 (12): 2775–9. doi:10.1097/00001756-199708180-00025. PMID 9295116. S2CID 21051920.
• Bolino A, Seri M, Caroli F, et al. (1999). "Exclusion of the SCN2B gene as candidate for CMT4B". Eur. J. Hum. Genet. 6 (6): 629–34. doi:10.1038/sj.ejhg.5200220. PMID 9887383.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Kim DY, Ingano LA, Carey BW, et al. (2005). "Presenilin/gamma-secretase-mediated cleavage of the voltage-gated sodium channel beta2-subunit regulates cell adhesion and migration". J. Biol. Chem. 280 (24): 23251–61. doi:10.1074/jbc.M412938200. PMID 15833746.

External links

• SCN2B+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Overview of all the structural information available in the PDB for UniProt: O60939 (Sodium channel subunit beta-2) at the PDBe-KB.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.