Stuart Jeffries of The Guardian said, "It’s gags galore in Sheridan Smith’s hilarious new comedy. The actor’s captivating turn as an out-of-control hedonist has a script stuffed with jokes."[4] Carol Midgley of The Times agreed, writing, "Some vehicles work better for Sheridan Smith than others, but Rosie Molloy Gives Up Everything is a rocket for her talent," concluding, "Its irreverence probably won’t please some. Rosie Molloy is a mess, but a damn funny one."[5] Sean O'Grady of The Independent praised the series' "great deal of dramatic tension", noting, "It’s comical, in the darkest kind of way. In Smith’s spirited (no pun intended) performance, our Rosie is a kind of engaging Mancunian good-time girl who’ll try anything once – and then get addicted to it."[6]