Khayat played college football for the Ole Miss Rebels and was selected in the sixth round of the 1960 NFL draft. He played for the Washington for three seasons, earning a Pro Bowl selection in 1960. After his football career, Khayat became a lawyer. He was appointed chancellor of the University of Mississippi in 1995.
Khayat played for the Redskins during the 1960, 1962, and 1963 seasons. Following the 1960 season, he was named to the Pro Bowl squad.[6] He appeared in a total of 40 NFL games and kicked 38 field goals and 90 extra points.[3]
His brother Eddie Khayat also played and coached in the NFL.[2]
He was appointed chancellor in 1995. In one of his first acts as chancellor, Khayat arranged for a $5.4 million gift from Jim and Sally Barksdale to establish an honors college at the university. In 1996, with enrollment declining, Khayat retained the public relations firm, Burson-Marsteller, to conduct a survey of public perception — including university symbols. When The New York Times reported on the review, which included the Confederate Flag and other Old South symbols, a media frenzy ensued.
On January 6, 2009, Khayat announced his retirement effective June 30, 2009.[8] He was succeeded by Daniel Jones on June 15, 2009.