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ROBO4
Identifiers
Aliases	ROBO4, ECSM4, MRB, roundabout guidance receptor 4, AOVD3
External IDs	OMIM: 607528; MGI: 1921394; HomoloGene: 10397; GeneCards: ROBO4; OMA:ROBO4 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	124,898,500 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	37,326,411 bp
RNA expression pattern
	Top expressed in
	lower lobe of lung; ; apex of heart; ; upper lobe of lung; ; upper lobe of left lung; ; spleen; ; sural nerve; ; subcutaneous adipose tissue; ; right lung; ; visceral pleura; ; endothelial cell;
	Top expressed in
	interventricular septum; ; muscle of thigh; ; left lung; ; right ventricle; ; digastric muscle; ; myocardium of ventricle; ; urethra; ; female urethra; ; left lung lobe; ; extraocular muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	signaling receptor activity; cell-cell adhesion mediator activity;
Cellular component	integral component of membrane; extracellular exosome; plasma membrane; axon;
Biological process	multicellular organism development; cell differentiation; regulation of cell migration; angiogenesis; homophilic cell adhesion via plasma membrane adhesion molecules; axon guidance; dendrite self-avoidance;
	Sources:Amigo / QuickGO
Orthologs
	54538
	74144
	ENSG00000154133
	ENSMUSG00000032125
	Q8WZ75
	Q8C310
	NM_001301088; NM_019055
	NM_028783; NM_001309390
	NP_001288017; NP_061928
	NP_001296319; NP_083059
	Wikidata
View/Edit Human	View/Edit Mouse

Roundabout homolog 4 is a protein that in humans is encoded by the ROBO4 gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000154133 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032125 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Huminiecki L, Bicknell R (November 2000). "In silico cloning of novel endothelial-specific genes". Genome Research. 10 (11): 1796–806. doi:10.1101/gr.150700. PMC 310981. PMID 11076864.
^ "Entrez Gene: ROBO4 roundabout homolog 4, magic roundabout (Drosophila)".

Schmucker D (September 2003). "Downstream of guidance receptors: entering the baroque period of axon guidance signaling". Neuron. 40 (1): 4–6. doi:10.1016/S0896-6273(03)00603-2. PMID 14527427. S2CID 15871522.
Huminiecki L, Gorn M, Suchting S, Poulsom R, Bicknell R (April 2002). "Magic roundabout is a new member of the roundabout receptor family that is endothelial specific and expressed at sites of active angiogenesis". Genomics. 79 (4): 547–52. doi:10.1006/geno.2002.6745. PMID 11944987.
Park KW, Morrison CM, Sorensen LK, Jones CA, Rao Y, Chien CB, Wu JY, Urness LD, Li DY (September 2003). "Robo4 is a vascular-specific receptor that inhibits endothelial migration". Developmental Biology. 261 (1): 251–67. doi:10.1016/S0012-1606(03)00258-6. PMID 12941633.
Bedell VM, Yeo SY, Park KW, Chung J, Seth P, Shivalingappa V, Zhao J, Obara T, Sukhatme VP, Drummond IA, Li DY, Ramchandran R (May 2005). "roundabout4 is essential for angiogenesis in vivo". Proceedings of the National Academy of Sciences of the United States of America. 102 (18): 6373–8. Bibcode:2005PNAS..102.6373B. doi:10.1073/pnas.0408318102. PMC 1088354. PMID 15849270.
Seth P, Lin Y, Hanai J, Shivalingappa V, Duyao MP, Sukhatme VP (July 2005). "Magic roundabout, a tumor endothelial marker: expression and signaling". Biochemical and Biophysical Research Communications. 332 (2): 533–41. doi:10.1016/j.bbrc.2005.03.250. PMID 15894287.
Liu T, Qian WJ, Gritsenko MA, Camp DG, Monroe ME, Moore RJ, Smith RD (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". Journal of Proteome Research. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.
Gröne J, Doebler O, Loddenkemper C, Hotz B, Buhr HJ, Bhargava S (June 2006). "Robo1/Robo4: differential expression of angiogenic markers in colorectal cancer". Oncology Reports. 15 (6): 1437–43. doi:10.3892/or.15.6.1437. PMID 16685377.
Okada Y, Yano K, Jin E, Funahashi N, Kitayama M, Doi T, Spokes K, Beeler DL, Shih SC, Okada H, Danilov TA, Maynard E, Minami T, Oettgen P, Aird WC (June 2007). "A three-kilobase fragment of the human Robo4 promoter directs cell type-specific expression in endothelium". Circulation Research. 100 (12): 1712–22. doi:10.1161/01.RES.0000269779.10644.dc. PMID 17495228.