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RASGRP3
Identifiers
Aliases	RASGRP3, GRP3, RAS guanyl releasing protein 3
External IDs	OMIM: 609531; MGI: 3028579; HomoloGene: 15019; GeneCards: RASGRP3; OMA:RASGRP3 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	33,564,750 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	75,836,049 bp
RNA expression pattern
	Top expressed in
	corpus callosum; ; inferior ganglion of vagus nerve; ; C1 segment; ; subthalamic nucleus; ; internal globus pallidus; ; superior vestibular nucleus; ; Pons; ; left ventricle; ; lymph node; ; muscle of thigh;
	Top expressed in
	iris; ; retinal pigment epithelium; ; endothelial cell of lymphatic vessel; ; mesenteric lymph nodes; ; lumbar subsegment of spinal cord; ; medial head of gastrocnemius muscle; ; triceps brachii muscle; ; sternocleidomastoid muscle; ; left lung lobe; ; primitive streak;
	More reference expression data
	n/a
Gene ontology
Molecular function	calcium ion binding; guanyl-nucleotide exchange factor activity; GTPase activator activity; signal transducer activity; metal ion binding; kinase binding; protein binding; diacylglycerol binding;
Cellular component	cytoplasm; plasma membrane; integral component of plasma membrane; perinuclear region of cytoplasm; guanyl-nucleotide exchange factor complex; intracellular anatomical structure;
Biological process	intracellular signal transduction; regulation of GTPase activity; small GTPase mediated signal transduction; MAPK cascade; positive regulation of GTPase activity; Ras protein signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	25780
	240168
	ENSG00000152689
	ENSMUSG00000071042
	Q8IV61
	Q6NZH9
NM_001139488; NM_015376; NM_170672; NM_001349975; NM_001349976;
	NM_001349977; NM_001349978; NM_001349979; NM_001349980; NM_001349981
	NM_001166493; NM_207246; NM_001360103
NP_001132960; NP_056191; NP_733772; NP_001336904; NP_001336905;
	NP_001336906; NP_001336907; NP_001336908; NP_001336909; NP_001336910
	NP_001159965; NP_997129; NP_001347032
	Wikidata
View/Edit Human	View/Edit Mouse

Ras guanyl-releasing protein 3 is a protein that in humans is encoded by the RASGRP3 gene.^[5]^[6]^[7]

Function

Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RASGRP3, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000).^[7]

Interactions

RASGRP3 has been shown to interact with PRKCD.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000152689 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000071042 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
^ Rebhun JF, Castro AF, Quilliam LA (Nov 2000). "Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interaction". The Journal of Biological Chemistry. 275 (45): 34901–8. doi:10.1074/jbc.M005327200. PMID 10934204.
^ ^a ^b "Entrez Gene: RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated)".
^ Brodie C, Steinhart R, Kazimirsky G, Rubinfeld H, Hyman T, Ayres JN, Hur GM, Toth A, Yang D, Garfield SH, Stone JC, Blumberg PM (Jul 2004). "PKCdelta associates with and is involved in the phosphorylation of RasGRP3 in response to phorbol esters". Molecular Pharmacology. 66 (1): 76–84. doi:10.1124/mol.66.1.76. PMID 15213298. S2CID 5774849.

Hartley JL, Temple GF, Brasch MA (Nov 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Lorenzo PS, Kung JW, Bottorff DA, Garfield SH, Stone JC, Blumberg PM (Feb 2001). "Phorbol esters modulate the Ras exchange factor RasGRP3". Cancer Research. 61 (3): 943–9. PMID 11221888.
Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Teixeira C, Stang SL, Zheng Y, Beswick NS, Stone JC (Aug 2003). "Integration of DAG signaling systems mediated by PKC-dependent phosphorylation of RasGRP3". Blood. 102 (4): 1414–20. doi:10.1182/blood-2002-11-3621. PMID 12730099.
Brodie C, Steinhart R, Kazimirsky G, Rubinfeld H, Hyman T, Ayres JN, Hur GM, Toth A, Yang D, Garfield SH, Stone JC, Blumberg PM (Jul 2004). "PKCdelta associates with and is involved in the phosphorylation of RasGRP3 in response to phorbol esters". Molecular Pharmacology. 66 (1): 76–84. doi:10.1124/mol.66.1.76. PMID 15213298. S2CID 5774849.
Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (Oct 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Aiba Y, Oh-hora M, Kiyonaka S, Kimura Y, Hijikata A, Mori Y, Kurosaki T (Nov 2004). "Activation of RasGRP3 by phosphorylation of Thr-133 is required for B cell receptor-mediated Ras activation". Proceedings of the National Academy of Sciences of the United States of America. 101 (47): 16612–7. Bibcode:2004PNAS..10116612A. doi:10.1073/pnas.0407468101. PMC 528733. PMID 15545601.
Roberts DM, Anderson AL, Hidaka M, Swetenburg RL, Patterson C, Stanford WL, Bautch VL (Dec 2004). "A vascular gene trap screen defines RasGRP3 as an angiogenesis-regulated gene required for the endothelial response to phorbol esters". Molecular and Cellular Biology. 24 (24): 10515–28. doi:10.1128/MCB.24.24.10515-10528.2004. PMC 533983. PMID 15572660.
Zheng Y, Liu H, Coughlin J, Zheng J, Li L, Stone JC (May 2005). "Phosphorylation of RasGRP3 on threonine 133 provides a mechanistic link between PKC and Ras signaling systems in B cells". Blood. 105 (9): 3648–54. doi:10.1182/blood-2004-10-3916. PMID 15657177.
Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (Jan 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Okamura SM, Oki-Idouchi CE, Lorenzo PS (Nov 2006). "The exchange factor and diacylglycerol receptor RasGRP3 interacts with dynein light chain 1 through its C-terminal domain". The Journal of Biological Chemistry. 281 (47): 36132–9. doi:10.1074/jbc.M605093200. PMID 17012239.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
Randhawa PK, Rylova S, Heinz JY, Kiser S, Fried JH, Dunworth WP, Anderson AL, Barber AT, Chappell JC, Roberts DM, Bautch VL (May 2011). "The Ras activator RasGRP3 mediates diabetes-induced embryonic defects and affects endothelial cell migration". Circulation Research. 108 (10): 1199–208. doi:10.1161/CIRCRESAHA.110.230888. PMC 3709466. PMID 21474816.