Primary cutaneous immunocytoma

Primary cutaneous immunocytoma
Specialty	Dermatology/Oncology

Primary cutaneous immunocytoma was initially regarded as a distinct type of the cutaneous lymphomas of the skin. (The "primary" used to designate cutaneous lymphomas indicates that the lymphoma was first diagnosed as limited to the skin and there was no evidence of spread to extracutaneous tissues for 6 months after the diagnosis was first made.^[1]) A 1997 review characterized 16 cases of primary cutaneious immunocytomo as skin lesions located on the arms and legs that in 15 of 16 cases had an excellent responses to, and prognoses after, purely local treatments. On microscopic histological examination, these lesions consisted of B cells (a type of lymphocyte) and nodular or diffuse infiltrates of lymphoplasmacytoid-like plasma cells located at the periphery of these infiltrates.^[2] In 2004, however, the World Health Organization (i.e., WHO) and European Organisation for Research and Treatment of Cancer (i.e., EORTC) classified primary cutaneous immunocytoma as one form of the primary cutaneous marginal zone lymphomas or, as they are now termed, primary cutaneous marginal zone lymphoproliferative disorders.^[3]

See also

• Primary cutaneous marginal zone lymphoma
• B-cell lymphoma
• Skin lesion

References

1. Magro CM, Porcu P, Ahmad N, Klinger D, Crowson AN, Nuovo G (September 2004). "Cutaneous immunocytoma: a clinical, histologic, and phenotypic study of 11 cases". Applied Immunohistochemistry & Molecular Morphology. 12 (3): 216–24. doi:10.1097/00129039-200409000-00006. PMID 15551734.
2. Rijlaarsdam JU, van der Putte SC, Berti E, Kerl H, Rieger E, Toonstra J, Geerts ML, Meijer CJ, Willemze R (August 1993). "Cutaneous immunocytomas: a clinicopathologic study of 26 cases". Histopathology. 23 (2): 117–25. doi:10.1111/j.1365-2559.1993.tb00469.x. PMID 8406383.
3. Willemze R, Jaffe ES, Burg G, Cerroni L, Berti E, Swerdlow SH, Ralfkiaer E, Chimenti S, Diaz-Perez JL, Duncan LM, Grange F, Harris NL, Kempf W, Kerl H, Kurrer M, Knobler R, Pimpinelli N, Sander C, Santucci M, Sterry W, Vermeer MH, Wechsler J, Whittaker S, Meijer CJ (May 2005). "WHO-EORTC classification for cutaneous lymphomas". Blood. 105 (10): 3768–85. doi:10.1182/blood-2004-09-3502. hdl:2434/566817. PMID 15692063.