Barzilla made his only major league appearance on June 11, 2006, for the Astros against the Atlanta Braves, and faced only two batters. Brian Jordan singled off Barzilla before Todd Pratt flew to center field to end the inning. Barzilla's 1/3rd of an inning is the second shortest career of an Astros pitcher after Larry Yount's appearance in which he was injured whilst warming up on the mound and never threw a pitch.