Wisgerhof made his debut in professional football, being part of the Vitesse squad in the 1999–2000 season. He was allowed to sign on loan with NEC for half a year. He then signed permanently with NEC, then played nine seasons for the club until making a switch in 2009 to Twente, who had sold defender Rob Wielaert to Ajax. Wisgerhof signed a contract with Twente for three-and-a-half years.[1] Here he has quickly played himself into the squad.
In 2011, Twente came second in the 2010–11 Eredivisie, behind Ajax. Wisgerhof played a notable role in this victory as he was claimed to have made an obvious schwalbe (dive), which was much commented on in the local and international press.[2] On 30 July 2011, Wisgerhof won his second Johan Cruyff Shield with Twente after his side again defeated Ajax, 2–1.