Born in Magdeburg, Seguin came through the academy system at 1. FC Lok Stendal in 1999. In 2007, he joined the VfL Wolfsburg Academy.[2] He was called up the second team in 2014. He made his professional debut in the Regionalliga Nord on 24 August 2014 against Hamburger SV II and on 6 December 2014, he scored his first goal of his career against VfR Neumünster.[3] He has played 36 games and scored 7 goals for VfL Wolfsburg II since 2014. On 4 March 2015, he made his debut for first team in DFB-Pokal against RB Leipzig. He played one minute after he replaced Kevin De Bruyne.[4]
On 17 January 2019, Seguin was loaned out to Greuther Fürth for the rest of the season with an option to buy.[5] On 7 May it was confirmed, that Greuther Fürth had decided to activate the option and he signed a three-year contract with the club.[6]
On 21 June 2023, Seguin agreed to join Schalke 04, newly relegated from the Bundesliga, signing a three-year contract.[7]