On February 6, 2014, President Barack Obama nominated Byron to serve as a United States district judge of the United States District Court for the Middle District of Florida, to the seat being vacated by Judge James S. Moody, Jr., who assumed senior status on March 31, 2014.[3] He received a hearing before the United States Senate Judiciary Committee on April 1, 2014.[4] On May 8, 2014, his nomination was reported out of committee by voice vote .[5] On June 19, 2014 Senate Majority LeaderHarry Reid filed a motion to invoke cloture on the nomination. On June 23, 2014 the United States Senate invoked cloture on his nomination by a 53–30 vote.[6] On Tuesday June 24, 2014, his nomination was confirmed by a 94–0 vote.[7] He received his judicial commission on the same day.[2]