The Hall was built to designs by architect James Gibbs for Sir John Astley in about 1730. The main façade is of three storeys with seven bays, three of which are pedimented, and tower wings. The west wing, of monolithic proportions, has four storeys. The house was set in a park of some 340 acres (1.4 km2) created by Capability Brown and including a large serpentine lake.
During the 20th century the house served as a rehabilitation centre in the 1940s and then until the 1980s as an orthopaedic hospital. In 1990 the estate was broken up and many acres were sold for the creation of a golf course; a classical temple created by Capability Brown was converted to become the clubhouse.
During the 1990s the house fell into disrepair and was briefly used as a school. In 1996 the house had suffered extensive decay and had deteriorated so badly that it appeared on the English heritage list of Buildings at Risk.
Patshull Hall was bought in 1997 by Neil Avery, a renovation specialist and entrepreneur, as a restoration project and the house was subsequently removed from the Buildings at Risk register. The Hall was later purchased in 2015. The house is being further renovated and is now used as a private family home.