On January 22, 2009, Perez finished the first 36 holes of the Bob Hope Classic with a 124 (−20), the lowest score, relative to par in PGA Tour history through two rounds. The start set or tied several records,[5] including tying the record for low score (124) in consecutive rounds. Perez went on to win the tournament by three strokes over John Merrick, a win secured when Perez hit his second shot on the par 5, 18th hole, from 200 yards to 3 feet to win with a closing eagle for his first tour win.
Perez also experienced a championship of another sort first-hand. As a neighbor of baseball player Pat Burrell, he had been very close to the Philadelphia Phillies for several years. In a January 2010 interview, he revealed, "I was part of that (2008) team (that won the World Series) because I know all of the guys, I had my locker there, I would come and see them all the time. I would really root for them like I was part of the team." When asked if he had the locker during spring training, he replied "No, the whole thing. I would hit balls with Jimmy Rollins, go out on the field and play catch, whatever. I was like one of them team for that year." When Burrell left as a free agent after the 2008 season and signed with the Tampa Bay Rays, Perez called the news "Worse than me getting hurt."[6]
Perez spent much of the 2015–16 season out of golf after shoulder surgery. He earned his first win since 2009 at the 2016 OHL Classic at Mayakoba.[7] He was also the first player since Harrison Frazar (2011St. Jude Classic) to win a PGA Tour event while playing on a Medical Extension. Perez won the CIMB Classic in 2017.[8]
As of June 2022, Perez no longer plays on the PGA Tour. He participates in LIV Golf.[9]
For the 2023 LIV Golf League season, Perez was signed to Dustin Johnson's 4Aces GC. He finished 28th in the individual standings and became a free agent after the season ended. On November 21, 2023, it was announced that Perez had re-signed with the 4Aces for the 2024 season.