Playing his youth career with Académie Darou Salam, he was a squad member for the 2017 Africa U-20 Cup of Nations,[1] where Senegal finished as runners-up.
He joined Norwegian second-tier side Aalesund ahead of the 2018 season.[2] He scored 22 goals for Aalesund in two seasons,[3] but also had disciplinary issues.[4]
On 29 August 2023, Guèye better known affectionately to the Dons fans as Mpape signed for Scottish Premiership club Aberdeen for an undisclosed fee on a three-year contract.[5]
On February 19, 2024, Guèye joined Norwegian side Kristiansund BK on loan, with Aberdeen Manager Neil Warnock stating "Pape needs to get out and play some regular football".[6]
On 19 July 2024 It was announced that Guèye had returned to Aberdeen.[7] Guèye scored five goals in the first five matches of the 2024–25 Scottish Premiership season.[8] On 2 October, it was reported that Guèye was ruled out until January 2025 with a quad muscle tear he picked up in training.[9]
^"SQUAD LISTS ANNOUNCED". Confederation of African Football. 24 February 2017. Archived from the original on 12 March 2017. Retrieved 24 February 2017.