Share to: share facebook share twitter share wa share telegram print page

PITRM1

PITRM1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPITRM1, MP1, PreP, pitrilysin metallopeptidase 1, SCAR30
External IDsOMIM: 618211 MGI: 1916867 HomoloGene: 5742 GeneCards: PITRM1
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_145131
NM_001360106

RefSeq (protein)

NP_660113
NP_001347035

Location (UCSC)Chr 10: 3.14 – 3.17 MbChr 13: 6.6 – 6.63 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Pitrilysin metallopeptidase 1 also known as presequence protease, mitochondrial (PreP) and metalloprotease 1 (MTP-1) is an enzyme that in humans is encoded by the PITRM1 gene.[5][6][7] It is also sometimes called metalloprotease 1 (MP1).PreP facilitates proteostasis by utilizing an ~13300-A(3) catalytic chamber to degrade toxic peptides, including mitochondrial presequences and β-amyloid.[8] Deficiency of PreP is found associated with Alzheimer's disease. Reduced levels of PreP via RNAi mediated knockdown have been shown to lead to defective maturation of the protein Frataxin.[9]

Structure

Gene

The PITRM1 gene is located at chromosome 10q15.2, consisting of 28 exons.

Protein

PreP is a 117 kDa M16C enzyme that is widely expressed in human tissues.[10] PreP is composed of PreP-N (aa 33-509) and PreP-C (aa 576-1037) domains, which are connected by an extended helical hairpin (aa 510-575). Its structure demonstrates that substrate selection by size-exclusion is a conserved mechanism in M16C proteases.[8]

Function

PreP is an Zn2+-dependent and ATP-independent metalloprotease, it does not select substrates on the basis of post-translational modifications or embedded degradation tags.[11][12][13] Instead, it uses a negatively charged catalytic chamber to engulf substrates peptides of up to ~65 residues while excluding larger, folded proteins.[14][15] It primarily localizes to the mitochondrial matrix, and cuts a range of peptides into recyclable fragments.[16][17] The substrates of PreP are vital to proteostasis, as they can insert to mitochondrial membranes, disrupting electrical potential and uncoupling respiration.[18][19] Thus deletion of PRTRM1 leads to a delayed growth phenotype.[20][21] Notabley, PreP degrades several functionally relevant Aβ species, the aggregates of which are toxic to the neuron and play a key role in AD pathogenesis.[22][14][23]

Clinical significance

PreP is the Aβ-degrading protease in mitochondria. Immune-depletion of PreP in brain mitochondria prevents degradation of mitochondrial Aβ, and PreP activity is found diminished in AD patients.[8] It has been reported that the loss of PreP activity is due to methionine oxidation and this study provides a rational basis for therapeutic intervention in conditions characterized by excessive oxidation of PreP.[24] A recent study also suggests that PreP regulates islet amyloid polypeptide in beta cells.[25] Two siblings carrying a homozygous PITRM1 missense mutation (c.548G>A, p.Arg183Gln) were reported to be associated with an autosomal recessive, slowly progressive syndrome. Clinical features include mental retardation, spinocerebellar ataxia, cognitive decline and psychosis.[26] A mouse model hemizygous for PITRM1 displayed progressive ataxia which was suggested to be linked to brain degenerative lesions, including accumulation of Aβ‐positive amyloid deposits. Recently, two brothers from a consanguineous family presenting with childhood-onset recessive cerebellar pathology were shown to carry a homozygous mutation in PITRM1 (c.2795C>T, p.T931M). This mutation resulted in 95% reduction in PITRM1 protein.[27] PITRM1 knockdown was shown to lead to reduced levels of mature Frataxin protein,[28] a protein that when deficient causes Friedreich's ataxia, and may be implicated in pathology in patients carrying PITRM1 mutations.

Interactions

PITRM1 has been shown to interact with the following proteins: CCL22, CGB2, DDX41, DEFB104A, HDHD3, MRPL12, NDUFV2, PRDX6, PRKCSH, RARS2, RIF1, SUCLG2, TEKT3, TERF2, and VAPB.[29]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000107959 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021193 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Marusov EV (July 1977). "[Ecological sterotypes of defensive behavior in fish under the action of chemical danger signals]". Nauchnye Doklady Vysshei Shkoly. Biologicheskie Nauki (8): 67–9. PMID 1036083.
  6. ^ Kikuno R, Nagase T, Ishikawa K, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (June 1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 6 (3): 197–205. doi:10.1093/dnares/6.3.197. PMID 10470851.
  7. ^ "Entrez Gene: PITRM1 pitrilysin metallopeptidase 1".
  8. ^ a b c King JV, Liang WG, Scherpelz KP, Schilling AB, Meredith SC, Tang WJ (July 2014). "Molecular basis of substrate recognition and degradation by human presequence protease". Structure. 22 (7): 996–1007. doi:10.1016/j.str.2014.05.003. PMC 4128088. PMID 24931469.
  9. ^ Nabhan JF, Gooch RL, Piatnitski Chekler EL, Pierce B, Bulawa CE (December 2015). "Perturbation of cellular proteostasis networks identifies pathways that modulate precursor and intermediate but not mature levels of frataxin". Scientific Reports. 5 (1): 18251. doi:10.1038/srep18251. PMC 4680912. PMID 26671574.
  10. ^ Mzhavia N, Berman YL, Qian Y, Yan L, Devi LA (May 1999). "Cloning, expression, and characterization of human metalloprotease 1: a novel member of the pitrilysin family of metalloendoproteases". DNA and Cell Biology. 18 (5): 369–80. doi:10.1089/104454999315268. PMID 10360838.
  11. ^ Malito E, Hulse RE, Tang WJ (August 2008). "Amyloid beta-degrading cryptidases: insulin degrading enzyme, presequence peptidase, and neprilysin". Cellular and Molecular Life Sciences. 65 (16): 2574–85. doi:10.1007/s00018-008-8112-4. PMC 2756532. PMID 18470479.
  12. ^ Ravid T, Hochstrasser M (September 2008). "Diversity of degradation signals in the ubiquitin-proteasome system". Nature Reviews. Molecular Cell Biology. 9 (9): 679–90. doi:10.1038/nrm2468. PMC 2606094. PMID 18698327.
  13. ^ Sauer RT, Baker TA (2011). "AAA+ proteases: ATP-fueled machines of protein destruction". Annual Review of Biochemistry. 80: 587–612. doi:10.1146/annurev-biochem-060408-172623. PMID 21469952.
  14. ^ a b Falkevall A, Alikhani N, Bhushan S, Pavlov PF, Busch K, Johnson KA, Eneqvist T, Tjernberg L, Ankarcrona M, Glaser E (September 2006). "Degradation of the amyloid beta-protein by the novel mitochondrial peptidasome, PreP". The Journal of Biological Chemistry. 281 (39): 29096–104. doi:10.1074/jbc.M602532200. PMID 16849325.
  15. ^ Johnson KA, Bhushan S, Ståhl A, Hallberg BM, Frohn A, Glaser E, Eneqvist T (May 2006). "The closed structure of presequence protease PreP forms a unique 10,000 Angstroms3 chamber for proteolysis". The EMBO Journal. 25 (9): 1977–86. doi:10.1038/sj.emboj.7601080. PMC 1456932. PMID 16601675.
  16. ^ Alikhani N, Berglund AK, Engmann T, Spånning E, Vögtle FN, Pavlov P, Meisinger C, Langer T, Glaser E (July 2011). "Targeting capacity and conservation of PreP homologues localization in mitochondria of different species". Journal of Molecular Biology. 410 (3): 400–10. doi:10.1016/j.jmb.2011.05.009. PMID 21621546.
  17. ^ Chow KM, Gakh O, Payne IC, Juliano MA, Juliano L, Isaya G, Hersh LB (April 2009). "Mammalian pitrilysin: substrate specificity and mitochondrial targeting". Biochemistry. 48 (13): 2868–77. doi:10.1021/bi8016125. PMC 2765508. PMID 19196155.
  18. ^ Koppen M, Langer T (2007). "Protein degradation within mitochondria: versatile activities of AAA proteases and other peptidases". Critical Reviews in Biochemistry and Molecular Biology. 42 (3): 221–42. doi:10.1080/10409230701380452. PMID 17562452. S2CID 6819247.
  19. ^ Mossmann D, Meisinger C, Vögtle FN (2012). "Processing of mitochondrial presequences". Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 1819 (9–10): 1098–106. doi:10.1016/j.bbagrm.2011.11.007. PMID 22172993.
  20. ^ Kambacheld M, Augustin S, Tatsuta T, Müller S, Langer T (May 2005). "Role of the novel metallopeptidase Mop112 and saccharolysin for the complete degradation of proteins residing in different subcompartments of mitochondria". The Journal of Biological Chemistry. 280 (20): 20132–9. doi:10.1074/jbc.M500398200. PMID 15772085.
  21. ^ Nilsson Cederholm S, Bäckman HG, Pesaresi P, Leister D, Glaser E (November 2009). "Deletion of an organellar peptidasome PreP affects early development in Arabidopsis thaliana". Plant Molecular Biology. 71 (4–5): 497–508. doi:10.1007/s11103-009-9534-6. PMID 19701724. S2CID 28627753.
  22. ^ Alikhani N, Guo L, Yan S, Du H, Pinho CM, Chen JX, Glaser E, Yan SS (2011). "Decreased proteolytic activity of the mitochondrial amyloid-β degrading enzyme, PreP peptidasome, in Alzheimer's disease brain mitochondria". Journal of Alzheimer's Disease. 27 (1): 75–87. doi:10.3233/JAD-2011-101716. hdl:1808/17858. PMC 3381900. PMID 21750375.
  23. ^ Pinho CM, Björk BF, Alikhani N, Bäckman HG, Eneqvist T, Fratiglioni L, Glaser E, Graff C (January 2010). "Genetic and biochemical studies of SNPs of the mitochondrial A beta-degrading protease, hPreP". Neuroscience Letters. 469 (2): 204–8. doi:10.1016/j.neulet.2009.11.075. PMID 19962426. S2CID 31073898.
  24. ^ Chen J, Teixeira PF, Glaser E, Levine RL (December 2014). "Mechanism of oxidative inactivation of human presequence protease by hydrogen peroxide". Free Radical Biology & Medicine. 77: 57–63. doi:10.1016/j.freeradbiomed.2014.08.016. PMC 4258540. PMID 25236746.
  25. ^ Guan H, Chow KM, Song E, Verma N, Despa F, Hersh LB (2015). "The Mitochondrial Peptidase Pitrilysin Degrades Islet Amyloid Polypeptide in Beta-Cells". PLOS ONE. 10 (7): e0133263. doi:10.1371/journal.pone.0133263. PMC 4507941. PMID 26191799.
  26. ^ Brunetti D, Torsvik J, Dallabona C, Teixeira P, Sztromwasser P, Fernandez-Vizarra E, et al. (March 2016). "Defective PITRM1 mitochondrial peptidase is associated with Aβ amyloidotic neurodegeneration". EMBO Molecular Medicine. 8 (3): 176–90. doi:10.15252/emmm.201505894. PMC 4772954. PMID 26697887.
  27. ^ Langer Y, Aran A, Gulsuner S, Abu Libdeh B, Renbaum P, Brunetti D, et al. (May 2018). "PITRM1 peptidase loss-of-function in childhood cerebellar atrophy". Journal of Medical Genetics. 55 (9): jmedgenet–2018–105330. doi:10.1136/jmedgenet-2018-105330. hdl:2434/622800. PMID 29764912. S2CID 21727945.
  28. ^ Nabhan JF, Gooch RL, Piatnitski Chekler EL, Pierce B, Bulawa CE (December 2015). "Perturbation of cellular proteostasis networks identifies pathways that modulate precursor and intermediate but not mature levels of frataxin". Scientific Reports. 5: 18251. doi:10.1038/srep18251. PMC 4680912. PMID 26671574.
  29. ^ "PITRM1 interaction network". BioGRID. Retrieved 6 August 2016.

Further reading

  • Schaeffer HJ, Catling AD, Eblen ST, Collier LS, Krauss A, Weber MJ (September 1998). "MP1: a MEK binding partner that enhances enzymatic activation of the MAP kinase cascade". Science. 281 (5383): 1668–71. doi:10.1126/science.281.5383.1668. PMID 9733512.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Baca informasi lainnya:

German biblical scholar, Old Testament professor, and Lutheran theologian Gerhard von RadThis file has no evidence of permission and may be deleted after Sunday, 3 September 2023.Born(1901-10-21)21 October 1901Nuremberg, Kingdom of Bavaria, German EmpireDied31 October 1971(1971-10-31) (aged 70)Heidelberg, West GermanyAlma mater University of Erlangen University of Tübingen ChurchConfessing ChurchWritingsThe Problem of the Hexateuch and Other Essays (1938)[1] Genesis: A Comment…

Siklus nitrogen di dalam tanah amat bergantung pada organisme tanah Biologi tanah adalah sebuah studi mengenai aktivitas mikroba dan fauna beserta ekologinya di dalam tanah. Fauna tanah, biota tanah, atau edafon adalah istilah yang biasanya digunakan untuk menyebut organisme yang menghabiskan sebagian besar siklus hidupnya di dalam tanah atau sedimen organik di atasnya. Fauna tanah mencakup cacing tanah, nematoda, fungi, bakteri, dan berbagai arthropoda. Dekomposisi materi organik oleh organimse…

Альфа-клітина На мікрофотознімку, зробленому за допомогою світлового мікроскопу, зображено острівець Лангерганса людиниДеталіІдентифікаториЛатина endocrinocytus ATH H3.04.02.0.00025FMA 70585Анатомічна термінологія[редагувати у Вікіданих] Альфа-клітина — це ендокринна клітина, що в

Ben-Hur Cartel de cine original, diseñado por Reynold Brown.Título Ben-HurFicha técnicaDirección William WylerProducción Sam ZimbalistGuion Karl TunbergNo acreditados:Gore VidalChristopher FryMaxwell AndersonS. N. BehrmanBasada en Ben-Hur, de Lewis WallaceMúsica Miklós RózsaSonido Sash Fisher William SteinkampFotografía Robert SurteesMontaje John D. Dunning Ralph E. WintersVestuario Elizabeth HaffendenEfectos especiales A. Arnold Gillespie Lee LeBlanc Robert R. HoagNarrador Finlay Curri…

Santa Cristina kan verwijzen naar: Santa Cristina (Mesão Frio), een plaats in Portugal Santa Cristina d'Aspromonte, een gemeente in de Italiaanse provincie Reggio Calabria, regio Calabrië Santa Cristina e Bissone, een gemeente in de Italiaanse provincie Pavia, regio Lombardije Santa Cristina Gela, een gemeente in de Italiaanse provincie Palermo, regio Sicilië Santa Cristina Gherdëina, een gemeente in de Italiaanse provincie Zuid-Tirol, regio Trentino-Zuid-Tirol Santa Cristina d'Aro, een geme…

1969 film by J. Lee Thompson The ChairmanTheatrical release posterDirected byJ. Lee ThompsonScreenplay byBen MaddowBased onThe Chairman1969 novelby Jay Richard KennedyProduced byMort AbrahamsArthur P. JacobsStarringGregory PeckAnne HeywoodArthur HillAlan DobieConrad YamaCinematographyJohn WilcoxTed Moore (uncredited)Edited byRichard BestMusic byJerry GoldsmithProductioncompanyAPJAC ProductionsDistributed by20th Century FoxRelease date 25 June 1969 (1969-06-25) Running time98 minut…

مايكل شين Michael Sheen مايكل شين في 2014 معلومات شخصية اسم الولادة مايكل كريستوفر شينMichael Christopher Sheen الميلاد 5 فبراير 1969 (العمر 54 سنة)نيوبورت، ويلز، المملكة المتحدة الإقامة لوس أنجلوس  مواطنة المملكة المتحدة ويلز  لون الشعر شعر بني  العشير كيت بيكينسيل (1995–2003)ساره سلفرمان (2014

Mountain range in Almería, Spain Location of S.Gador in the Almería relief map Sierra de Gádor of Sierra Gador is a mountain range in southwest of the province of Almería, Spain.[1][2] It is bordered to the north by Sierra Nevada and to the south by the Mediterranean Sea. Morrón de la Lagunilla summit It is a isolated massif in an arid and semi-arid complex. It has a very uneven relief. The highest peaks are Morrón de la Lagunilla [es] (2,247 m), Pico Colorado …

Helena Helena (aktif di abad ke-4 SM di Mesir) merupakan seorang pelukis yang belajar keahliannya dari ayahandanya, Timon, yang juga adalah seorang seniman. Ia bekerja di periode setelah kematian Aleksander Agung pada tahun 323 SM. Helena melukis adegan Aleksander mengalahkan penguasa Persia, Darius III, di Pertempuran Issos di Anatolia Selatan.[1][2] Plinius yang Tua menulis bahwa “Pertempuran Issos” adalah karya Helena satu-satunya yang tercatat, dimana ada reproduksi mosai…

2019 film by Paul Downs Colaizzo Brittany Runs a MarathonTheatrical release posterDirected byPaul Downs ColaizzoWritten byPaul Downs ColaizzoProduced by Matthew Plouffe Tobey Maguire Margot Hand Starring Jillian Bell Michaela Watkins Utkarsh Ambudkar Lil Rel Howery Micah Stock CinematographySeamus TierneyEdited byCasey BrooksMusic byDuncan ThumProductioncompanies Material Pictures Picture Films Distributed byAmazon StudiosRelease dates January 28, 2019 (2019-01-28) (Sundance) …

Digital camera model Kodak EasyShare C813 The Easyshare C813 is a discontinued digital camera made by Kodak. It features an 8.2-megapixel camera with 3× optical zoom; a 2.4-inch colour LCD display; digital image stabilization; high ISO setting (up to 1250); video capture; 16 scene modes and three colour modes; on-camera picture enhancement and editing tools; 16 MB on-camera storage, expandable with an SD card. The manufacturer recommends 2 GB SDHC and claims 16 GB is the maximum.…

Lithuanian professional basketball player Jonas ValančiūnasValančiūnas in 2022No. 17 – New Orleans PelicansPositionCenterLeagueNBAPersonal informationBorn (1992-05-06) 6 May 1992 (age 31)Utena, LithuaniaListed height6 ft 11 in (2.11 m)Listed weight265 lb (120 kg)Career informationNBA draft2011: 1st round, 5th overall pickSelected by the Toronto RaptorsPlaying career2008–presentCareer history2008–2010Perlas Vilnius2010–2012Lietuvos rytas Vilnius20…

South Korean judoka Not to be confused with Kim Mi-jung (judoka, born 1978). In this Korean name, the family name is Kim. Kim Mi-jungPersonal informationBorn29 March 1971 (1971-03-29) (age 52)Masan, Gyeongsangnam-doOccupationJudokaKorean nameHangul김미정Hanja金美廷Revised RomanizationKim Mi-jeongMcCune–ReischauerKim Mi-jŏng SportCountrySouth KoreaSportJudoWeight class‍–‍72 kgAchievements and titlesOlympic Games (1992)World Champ. (1991)Asian Champ. (1994) Medal record Wo…

Pakistani TV series or programme Daray Daray NainaCoverGenreDramaWritten byK RehmanDirected byDilawar MalikStarringBabar AliSami KhanMehmood AslamNeelam MunirZhalay SarhadiShahood AlviTheme music composerOwais MasoodOpening themewritten by Sabir Zafarperformed by Shreya GhoshalCountry of originPakistanOriginal languageUrduNo. of episodes10ProductionProducersChaudhry Muhammad ArshadChauhdhry Muhammad AshrafProduction locationThailandOriginal releaseNetworkA-Plus EntertainmentRelease6 No…

Sebuah papan peringatan dalam empat bahasa resmi di Singapura yang ditemukan di seluruh stasiun MRT Singapura Kehidupan di Singapura Budaya Tarian Demografi Berkendara Ekonomi Pendidikan Film Hari raya Bahasa Sastra Musik Politik Agama Bahasa Inggris Singapura Olahraga Transportasi Konskripsi lbs Menurut Konstitusi Singapura,[1] empat bahasa resmi di Singapura adalah bahasa Melayu, Mandarin, Tamil, dan Inggris, sementara bahasa nasionalnya adalah Melayu.[2] Tiga bahasa selain bah…

This article does not cite any sources. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed.Find sources: Simplemente Todo – news · newspapers · books · scholar · JSTOR (December 2014) (Learn how and when to remove this template message) 1986 studio album by Verónica CastroSimplemente TodoStudio album by Verónica CastroReleased1986 (1986)Recorded1986GenrePopLabelImDiscos…

Pattern of five points, four in a square or rectangle and a fifth at its center For other uses, see Quincunx (disambiguation). A quincunx of pips on the five-side of a die A quincunx (/ˈkwɪn.kʌŋks/ KWIN-kunks) is a geometric pattern consisting of five points arranged in a cross, with four of them forming a square or rectangle and a fifth at its center.[1] The same pattern has other names, including in saltire or in cross in heraldry (depending on the orientation of the outer square),…

Horror novel written in 2019 by Ursula Vernon This article is about the 2019 horror novel. For the 2017 Five Nights at Freddy novel, see Five Nights At Freddy's: The Twisted Ones. The Twisted Ones AuthorT. KingfisherAudio read byHillary HuberCountryUnited StatesLanguageEnglishPublished2019PublisherGallery/Saga PressMedia typePrint (hardback, paperback), ebook, audiobookPages400 pagesISBN978-1534429574 First edition US hardcover The Twisted Ones is a 2019 horror novel written by Ur…

この記事は検証可能な参考文献や出典が全く示されていないか、不十分です。出典を追加して記事の信頼性向上にご協力ください。(このテンプレートの使い方)出典検索?: Avex trax – ニュース · 書籍 · スカラー · CiNii · J-STAGE · NDL · dlib.jp · ジャパンサーチ · TWL(2023年7月) この項目には、JIS X 0213:2004 で規定されている文字(…

Symphonic poem by Franz Liszt This article uses bare URLs, which are uninformative and vulnerable to link rot. Please consider converting them to full citations to ensure the article remains verifiable and maintains a consistent citation style. Several templates and tools are available to assist in formatting, such as reFill (documentation) and Citation bot (documentation). (August 2022) (Learn how and when to remove this template message) Prometheus, by Gustave Moreau Franz Liszt composed his P…

2020 American filmButt BoyDirected byTyler CornackWritten by Tyler Cornack Ryan Koch Produced by Ryan Koch Brian Wolfe CinematographyBilly MoreanEdited byAustin LewisMusic byFeathersProductioncompanyEpic PicturesRelease dateApril 14, 2020CountryThe United StatesLanguageEnglish Butt Boy is a 2020 American comedy drama written and directed by Tyler Cornack in his directorial debut. The film is a spinoff from a Tiny Cinema comedy sketch. Premise Chip Gutchell, an IT specialist and recovering alcoho…

American rock band This article is about the original band. For the spin-off band Kyuss Lives!, see Vista Chino. For the fictional deity, see Kyuss (Greyhawk). KyussKyuss c. 1992. Left to right: Josh Homme, Brant Bjork, John Garcia, Nick Oliveri.Background informationAlso known asKatzenjammer (1987–1989)Sons of Kyuss (1989–1991)OriginPalm Desert, California, U.S.Genres Stoner rock[1] desert rock[2] heavy metal[3] DiscographyKyuss discographyYears active1987–19…

Highest-ranking official in Samara Oblast, Russia Governor of Samara OblastStandard of the GovernorIncumbentDmitry Azarovsince 17 September 2018SeatSamaraTerm length5 yearsFormation1991Websitewww.samregion.ru The Governor of Samara Oblast (Russian: Губернатор Самарской области) is the head of government of Samara Oblast, a federal subject of Russia. The position was introduced in 1991 as Head of Administration of Samara Oblast. The Governor is elected by direct pop…

Not to be confused with Commonwealth Railways. This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed.Find sources: Commonwealth Railway – news · newspapers · books · scholar · JSTOR (November 2017) (Learn how and when to remove this template message) Commonwealth Railway, Inc.OverviewHeadquartersSuffolk, VAReporting markCWRYLocale…

Railway station in Fukuyama, Hiroshima Prefecture, Japan Kamitode Station上戸手駅Kamitode Station, November 2023General informationLocation261-2 Tode Shinichi-chō, Fukuyama-shi, Hiroshima-ken 729-3101JapanCoordinates34°33′5.96″N 133°16′54.79″E / 34.5516556°N 133.2818861°E / 34.5516556; 133.2818861Owned by West Japan Railway CompanyOperated by West Japan Railway CompanyLine(s)Z Fukuen LineDistance18.8 km (11.7 mi) from FukuyamaPlatforms1 side pla…

SivaSiva di Maniar Family Audio Launch. 2018LahirSivakumar JayakumarChennai, Tamil Nadu, IndiaPekerjaanSinematograferSutradaraPenulis naskahTahun aktif2002–sekarang Sivakumar Jayakumar, yang lebih dikenal sebagai Siva atau Cheetah, adalah seorang pembuat film yang berkarya dalam sinema Tamil sebagai sinematografer, sutradara dan pemeran. Kehidupan pribadi Siva Kumar lahir dari fotografer dokumenter Jayakumar di Chennai;[1] bahasa ibunya adalah Tamil.[2] Ia adalah cucu dari…

1963 single by Freddie and the DreamersI'm Telling You NowSingle by Freddie and the DreamersB-sideWhat Have I Done to You?Released September 1963 (1963-09) (UK) March 1965 (1965-03) (US) GenreMerseybeat[1]Length2:05LabelColumbia (EMI) DB 7086 (UK)Tower 125 (USA)Songwriter(s)Freddie Garrity, Mitch MurrayProducer(s)John BurgessFreddie and the Dreamers singles chronology If You Gotta Make a Fool of Somebody (1963) I'm Telling You Now (1963) You Were Made for Me (1963) I'…

Mycetophila fraterna Klasifikasi ilmiah Kerajaan: Animalia Filum: Arthropoda Kelas: Insecta Ordo: Diptera Famili: Mycetophilidae Genus: Mycetophila Spesies: Mycetophila fraterna Mycetophila fraterna adalah spesies lalat yang berasal dari genus Mycetophila dan famili Mycetophilidae. Lalat ini juga merupakan bagian dari ordo Diptera, kelas Insecta, filum Arthropoda, dan kingdom Animalia. Lalat ini biasanya dapat ditemui di tempat lembab. Referensi Bisby F.A., Roskov Y.R., Orrell T.M., Nicolson D.,…

For other ships with the same name, see HMAS Westralia. HMAS Westralia after conversion to an LSI in 1944 History Name Westralia (1929–59) Delfino (1959–1960) Woolambi (1960–1961) Owner Huddart Parker, Melbourne (1929–1959) Asian & Pacific Shipping Company, Fiji (1959–1961) BuilderHarland and Wolff, Govan Yard number843 Launched25 April 1929 Completed1929 Identification UK official number: 153935 Code letters: LDRC FateSold for scrap in 1961 History Australia NameWestralia Acquired…

Oceania Rugby Men's Sevens ChampionshipMost recent season or competition:2023 Oceania Sevens ChampionshipSportRugby sevensFirst season2008; 16 years ago (2008)Most recentchampion(s) New Zealand (2023)Most titles Fiji (5 titles) The Oceania Rugby Men's Sevens Championship is an international rugby sevens competition organised by Oceania Rugby. It has been held regularly since 2008 to select the best men's national team in Oceania. Participating teams Men's teams co…

Kembali kehalaman sebelumnya