Each structure in the PDBsum database includes an image of structure (main view, Bottom view and right view), molecular components contained in the complex(structure), enzyme reaction diagram if appropriate, Gene ontology functional assignments, a 1D sequence annotated by Pfam and InterPro domain assignments, description of bound molecules and graphic showing interactions between protein and secondary structure, schematic diagrams of protein–protein interactions, analysis of clefts contained within the structure and links to external databases.[6] The RasMol and Jmol molecular graphics software are used to provide a 3D view of molecules and their interactions within PDBsum.[5]
Since the release of the 1000 Genomes Project in October 2012, all single amino acid variants identified by the project have been mapped to the corresponding protein sequences in the Protein Data Bank. These variants are also displayed within PDBsum, cross-referenced to the relevant UniProt identifier.[6] PDBsum contains a number of protein structures that may be of interest in structure-based drug design. One branch of PDBsum, known as DrugPort, focuses on these models and is linked with the DrugBank drug target database.[6][7]
^Laskowski RA, Hutchinson EG, Michie AD, Wallace AC, Jones ML, Thornton JM (Dec 1997). "PDBsum: a Web-based database of summaries and analyses of all PDB structures". Trends in Biochemical Sciences. 22 (12): 488–90. doi:10.1016/S0968-0004(97)01140-7. PMID9433130.
