The first settlement there was around 1802, where there was a mill operated at various times by Nebo Gaunt, Ignatius Brown, and David Brown. Around 1820, it was known as Freeport.[3] The Little Miami Railroad reached the village c. 1845. A post office called Oregon was established in 1846, and the name was changed to Oregonia in 1882.[4] The post office has since been consolidated with the Lebanon post office.
Today, Oregonia is a stop on the Little Miami Bike Trail which follows the former train route along the Little Miami River. Bikers, hikers, and canoers often stop at the market or a restaurant along the trail which follows the river on the former train route. In October of each year, the "Devils Staircase" motorcycle hill climb is held on a hill just south of the main settlement.