Jet-boats are commonly used to access these tributaries and the upper Nushagak. The Wood River, Iowithla River and the Kokwok River are smaller tributaries.
The Nushagak River is downstream of the proposed Pebble Mine, whose tailings storage lake would sit at the headwaters of the Koktuli River, one of the Nushagak's tributaries. Villages on the Nushagak are among the major opponents of the proposal[citation needed].
Five species of Pacific salmon (Chinook, coho, sockeye, chum, and pink) spawn in the river or its tributaries. Commercial, subsistence and sport fishing are important in the area. Most notable is the annual run of king (Chinook) salmon which occurs from mid-June to mid-July. Rainbow trout, northern pike, grayling, burbot, whitefish and Arctic char are also present in the Nushagak. It is estimated that over 50% of the world's production of wild salmon is harvested in the Nushagak River and the Bristol Bay area.
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