Jović made his senior debut for Mega Basket in February 2021 at the Radivoj Korać Cup tournament in Novi Sad. On 19 March, Jović made his ABA League debut in a 74–65 loss to Split recording 10 points and 9 rebounds in 21 minutes of playing time.[7] On 10 June 2021, one day after his 18th birthday he signed his first professional contract with Mega.[8][9]
In the NBA.comGM Survey for the 2021–22 NBA season, Jović received votes for the best international player not playing in the NBA.[10] In April 2022, he was named the ABA League Top Prospect for the 2021–22 season.[11][12] During the 2021–22 season, Jović averaged 11.7 points while shooting 42.8 percent from the field, 35.6 percent on threes and 75.4 percent from the free throw, 4.4 rebounds, 3.4 assists to 2.7 turnovers and 0.4 blocks per game in 25 appearances.[13]
On 23 October 2022, Jović was suspended for one game without pay for leaving the bench during an altercation between the Heat and the Toronto Raptors the night before.[22] He was assigned to the NBA G League on 30 December 2022.[23] Jović made the 2023 NBA Finals but the Heat lost the series in 5 games to the Denver Nuggets.
On February 13, 2024, Jović scored a career-high 24 points, with 7 rebounds, in a 123–97 win against the Milwaukee Bucks.[24]