SR 225 begins at the intersection of SR 535/Interstate 80 Business Loop (Idaho Street) and Silver Street just west of downtown Elko. From there it heads northwesterly along the east side of Elko Regional Airport and then has a junction with Interstate 80. The road continues northwest, winding its way up a narrow valley on its way to Adobe Summit in the Adobe Range. From there, it heads generally north, passing the small ghost town of Dinner Station before intersecting Deep Creek Highway (SR 226) at Tuscarora Junction. It then continues generally north, passing North Fork and intersecting various county routes before reaching Wild Horse on the south shore of Wild Horse Reservoir. The road winds its way along the east and north shores of the reservoir before entering the narrow and windy canyon of the Owyhee River. After the canyon widens into a somewhat broader valley, SR 225 passes through Mountain City. Continuing northwest, the valley becomes much wider just before the road enters Owyhee. A few miles north of Owyhee, the road crosses into Idaho and becomes SH-51.