Nanotechnology was defined by the National Nanotechnology Initiative as the manipulation of matter with at least one dimension sized from 1 to 100 nanometers (nm). At this scale, commonly known as the nanoscale, surface area and quantum mechanical effects become important in describing properties of matter. The definition of nanotechnology is inclusive of all types of research and technologies that deal with these special properties. It is therefore common to see the plural form "nanotechnologies" as well as "nanoscale technologies" to refer to the broad range of research and applications whose common trait is size.[1] An earlier description of nanotechnology referred to the particular technological goal of precisely manipulating atoms and molecules for fabrication of macroscale products, also now referred to as molecular nanotechnology.[2]
Scientists currently debate the future implications of nanotechnology. Nanotechnology may be able to create many new materials and devices with a vast range of applications, such as in nanomedicine, nanoelectronics, biomaterials energy production, and consumer products. On the other hand, nanotechnology raises many of the same issues as any new technology, including concerns about the toxicity and environmental impact of nanomaterials,[9] and their potential effects on global economics, as well as speculation about various doomsday scenarios. These concerns have led to a debate among advocacy groups and governments on whether special regulation of nanotechnology is warranted.
The concepts that seeded nanotechnology were first discussed in 1959 by physicist Richard Feynman in his talk There's Plenty of Room at the Bottom, in which he described the possibility of synthesis via direct manipulation of atoms.
The term "nano-technology" was first used by Norio Taniguchi in 1974, though it was not widely known. Inspired by Feynman's concepts, K. Eric Drexler used the term "nanotechnology" in his 1986 book Engines of Creation: The Coming Era of Nanotechnology, which proposed the idea of a nanoscale "assembler" which would be able to build a copy of itself and of other items of arbitrary complexity with atomic control. Also in 1986, Drexler co-founded The Foresight Institute (with which he is no longer affiliated) to help increase public awareness and understanding of nanotechnology concepts and implications.
The emergence of nanotechnology as a field in the 1980s occurred through convergence of Drexler's theoretical and public work, which developed and popularized a conceptual framework for nanotechnology, and high-visibility experimental advances that drew additional wide-scale attention to the prospects of atomic control of matter. In the 1980s, two major breakthroughs sparked the growth of nanotechnology in the modern era. First, the invention of the scanning tunneling microscope in 1981 which enabled visualization of individual atoms and bonds, and was successfully used to manipulate individual atoms in 1989. The microscope's developers Gerd Binnig and Heinrich Rohrer at IBM Zurich Research Laboratory received a Nobel Prize in Physics in 1986.[10][11] Binnig, Quate and Gerber also invented the analogous atomic force microscope that year.
In the early 2000s, the field garnered increased scientific, political, and commercial attention that led to both controversy and progress. Controversies emerged regarding the definitions and potential implications of nanotechnologies, exemplified by the Royal Society's report on nanotechnology.[15] Challenges were raised regarding the feasibility of applications envisioned by advocates of molecular nanotechnology, which culminated in a public debate between Drexler and Smalley in 2001 and 2003.[16]
Meanwhile, commercialization of products based on advancements in nanoscale technologies began emerging. These products are limited to bulk applications of nanomaterials and do not involve atomic control of matter. Some examples include the Silver Nano platform for using silver nanoparticles as an antibacterial agent, nanoparticle-based transparent sunscreens, carbon fiber strengthening using silica nanoparticles, and carbon nanotubes for stain-resistant textiles.[17][18]
By the mid-2000s new and serious scientific attention began to flourish. Projects emerged to produce nanotechnology roadmaps[19][20] which center on atomically precise manipulation of matter and discuss existing and projected capabilities, goals, and applications.
Fundamental concepts
Nanotechnology is the science and engineering of functional systems at the molecular scale. This covers both current work and concepts that are more advanced. In its original sense, nanotechnology refers to the projected ability to construct items from the bottom up, using techniques and tools being developed today to make complete, high-performance products.
One nanometer (nm) is one billionth, or 10−9, of a meter. By comparison, typical carbon–carbon bond lengths, or the spacing between these atoms in a molecule, are in the range 0.12–0.15 nm, and a DNA double-helix has a diameter around 2 nm. On the other hand, the smallest cellular life-forms, the bacteria of the genus Mycoplasma, are around 200 nm in length. By convention, nanotechnology is taken as the scale range 1 to 100 nm following the definition used by the National Nanotechnology Initiative in the US. The lower limit is set by the size of atoms (hydrogen has the smallest atoms, which are approximately a quarter of a nm kinetic diameter) since nanotechnology must build its devices from atoms and molecules. The upper limit is more or less arbitrary but is around the size below which the phenomena not observed in larger structures start to become apparent and can be made use of in the nano device.[21] These new phenomena make nanotechnology distinct from devices that are merely miniaturized versions of an equivalent macroscopic device; such devices are on a larger scale and come under the description of microtechnology.[22]
To put that scale in another context, the comparative size of a nanometer to a meter is the same as that of a marble to the size of the earth.[23] Or another way of putting it: a nanometer is the amount an average man's beard grows in the time it takes him to raise the razor to his face.[23]
Two main approaches are used in nanotechnology. In the "bottom-up" approach, materials and devices are built from molecular components which assemble themselves chemically by principles of molecular recognition.[24] In the "top-down" approach, nano-objects are constructed from larger entities without atomic-level control.[25]
Several phenomena become pronounced as the size of the system decreases. These include statistical mechanical effects, as well as quantum mechanical effects, for example the "quantum size effect" where the electronic properties of solids are altered with great reductions in particle size. This effect does not come into play by going from macro to micro dimensions. However, quantum effects can become significant when the nanometer size range is reached, typically at distances of 100 nanometers or less, the so-called quantum realm. Additionally, a number of physical (mechanical, electrical, optical, etc.) properties change when compared to macroscopic systems. One example is the increase in surface area to volume ratio altering mechanical, thermal and catalytic properties of materials. Diffusion and reactions at the nanoscale can be different, for instance in nanostructured materials and nanodevices. Systems with fast ion transport are referred to as nanoionics. The mechanical properties of nanosystems are of interest in the nanomechanics research. The catalytic activity of nanomaterials also opens potential risks in their interaction with biomaterials.
Materials reduced to the nanoscale can show different properties compared to what they exhibit on a macroscale, enabling unique applications. For instance, opaque substances can become transparent (copper); stable materials can turn combustible (aluminium); insoluble materials may become soluble (gold). A material such as gold, which is chemically inert at normal scales, can serve as a potent chemical catalyst at nanoscales. Much of the fascination with nanotechnology stems from these quantum and surface phenomena that matter exhibits at the nanoscale.[26]
Modern synthetic chemistry has reached the point where it is possible to prepare small molecules to almost any structure. These methods are used today to manufacture a wide variety of useful chemicals such as pharmaceuticals or commercial polymers. This ability raises the question of extending this kind of control to the next-larger level, seeking methods to assemble these single molecules into supramolecular assemblies consisting of many molecules arranged in a well defined manner.
These approaches utilize the concepts of molecular self-assembly and/or supramolecular chemistry to automatically arrange themselves into some useful conformation through a bottom-up approach. The concept of molecular recognition is especially important: molecules can be designed so that a specific configuration or arrangement is favored due to non-covalentintermolecular forces. The Watson–Crick basepairing rules are a direct result of this, as is the specificity of an enzyme being targeted to a single substrate, or the specific folding of the protein itself. Thus, two or more components can be designed to be complementary and mutually attractive so that they make a more complex and useful whole.
Such bottom-up approaches should be capable of producing devices in parallel and be much cheaper than top-down methods, but could potentially be overwhelmed as the size and complexity of the desired assembly increases. Most useful structures require complex and thermodynamically unlikely arrangements of atoms. Nevertheless, there are many examples of self-assembly based on molecular recognition in biology, most notably Watson–Crick basepairing and enzyme-substrate interactions. The challenge for nanotechnology is whether these principles can be used to engineer new constructs in addition to natural ones.
Molecular nanotechnology, sometimes called molecular manufacturing, describes engineered nanosystems (nanoscale machines) operating on the molecular scale. Molecular nanotechnology is especially associated with the molecular assembler, a machine that can produce a desired structure or device atom-by-atom using the principles of mechanosynthesis. Manufacturing in the context of productive nanosystems is not related to, and should be clearly distinguished from, the conventional technologies used to manufacture nanomaterials such as carbon nanotubes and nanoparticles.
When the term "nanotechnology" was independently coined and popularized by Eric Drexler (who at the time was unaware of an earlier usage by Norio Taniguchi) it referred to a future manufacturing technology based on molecular machine systems. The premise was that molecular-scale biological analogies of traditional machine components demonstrated molecular machines were possible: by the countless examples found in biology, it is known that sophisticated, stochastically optimized biological machines can be produced.
It is hoped that developments in nanotechnology will make possible their construction by some other means, perhaps using biomimetic principles. However, Drexler and other researchers[27] have proposed that advanced nanotechnology, although perhaps initially implemented by biomimetic means, ultimately could be based on mechanical engineering principles, namely, a manufacturing technology based on the mechanical functionality of these components (such as gears, bearings, motors, and structural members) that would enable programmable, positional assembly to atomic specification.[28] The physics and engineering performance of exemplar designs were analyzed in Drexler's book Nanosystems: Molecular Machinery, Manufacturing, and Computation.[2]
In general it is very difficult to assemble devices on the atomic scale, as one has to position atoms on other atoms of comparable size and stickiness. Another view, put forth by Carlo Montemagno,[29] is that future nanosystems will be hybrids of silicon technology and biological molecular machines. Richard Smalley argued that mechanosynthesis are impossible due to the difficulties in mechanically manipulating individual molecules.
This led to an exchange of letters in the ACS publication Chemical & Engineering News in 2003.[30] Though biology clearly demonstrates that molecular machine systems are possible, non-biological molecular machines are today only in their infancy. Leaders in research on non-biological molecular machines are Alex Zettl and his colleagues at Lawrence Berkeley Laboratories and UC Berkeley.[31] They have constructed at least three distinct molecular devices whose motion is controlled from the desktop with changing voltage: a nanotube nanomotor, a molecular actuator,[32] and a nanoelectromechanical relaxation oscillator.[33] See nanotube nanomotor for more examples.
An experiment indicating that positional molecular assembly is possible was performed by Ho and Lee at Cornell University in 1999. They used a scanning tunneling microscope to move an individual carbon monoxide molecule (CO) to an individual iron atom (Fe) sitting on a flat silver crystal, and chemically bound the CO to the Fe by applying a voltage.
Current research
Nanomaterials
The nanomaterials field includes subfields which develop or study materials having unique properties arising from their nanoscale dimensions.[36]
Interface and colloid science has given rise to many materials which may be useful in nanotechnology, such as carbon nanotubes and other fullerenes, and various nanoparticles and nanorods. Nanomaterials with fast ion transport are related to nanoionics and nanoelectronics.
Nanoscale materials can also be used for bulk applications; most present commercial applications of nanotechnology are of this flavor.
Progress has been made in using these materials for medical applications; see Nanomedicine.
Nanoscale materials such as nanopillars are sometimes used in solar cells which combats the cost of traditional silicon solar cells.
Development of applications incorporating semiconductor nanoparticles to be used in the next generation of products, such as display technology, lighting, solar cells and biological imaging; see quantum dots.
These seek to arrange smaller components into more complex assemblies.
DNA nanotechnology utilizes the specificity of Watson–Crick basepairing to construct well-defined structures out of DNA and other nucleic acids.
Approaches from the field of "classical" chemical synthesis (Inorganic and organic synthesis) also aim at designing molecules with well-defined shape (e.g. bis-peptides[42]).
More generally, molecular self-assembly seeks to use concepts of supramolecular chemistry, and molecular recognition in particular, to cause single-molecule components to automatically arrange themselves into some useful conformation.
Molecular Beam Epitaxy allows for bottom up assemblies of materials, most notably semiconductor materials commonly used in chip and computing applications, stacks, gating, and nanowire lasers.
Top-down approaches
These seek to create smaller devices by using larger ones to direct their assembly.
Many technologies that descended from conventional solid-state silicon methods for fabricating microprocessors are now capable of creating features smaller than 100 nm, falling under the definition of nanotechnology. Giant magnetoresistance-based hard drives already on the market fit this description,[43] as do atomic layer deposition (ALD) techniques. Peter Grünberg and Albert Fert received the Nobel Prize in Physics in 2007 for their discovery of Giant magnetoresistance and contributions to the field of spintronics.[44]
Focused ion beams can directly remove material, or even deposit material when suitable precursor gasses are applied at the same time. For example, this technique is used routinely to create sub-100 nm sections of material for analysis in Transmission electron microscopy.
Atomic force microscope tips can be used as a nanoscale "write head" to deposit a resist, which is then followed by an etching process to remove material in a top-down method.
Functional approaches
These seek to develop components of a desired functionality without regard to how they might be assembled.
Magnetic assembly for the synthesis of anisotropic superparamagnetic materials such as recently presented magnetic nano chains.[24]
Molecular scale electronics seeks to develop molecules with useful electronic properties. These could then be used as single-molecule components in a nanoelectronic device.[45] For an example see rotaxane.
Bionics or biomimicry seeks to apply biological methods and systems found in nature, to the study and design of engineering systems and modern technology. Biomineralization is one example of the systems studied.
These subfields seek to anticipate what inventions nanotechnology might yield, or attempt to propose an agenda along which inquiry might progress. These often take a big-picture view of nanotechnology, with more emphasis on its societal implications than the details of how such inventions could actually be created.
Molecular nanotechnology is a proposed approach which involves manipulating single molecules in finely controlled, deterministic ways. This is more theoretical than the other subfields, and many of its proposed techniques are beyond current capabilities.
Nanorobotics centers on self-sufficient machines of some functionality operating at the nanoscale. There are hopes for applying nanorobots in medicine.[49][50] Nevertheless, progress on innovative materials and methodologies has been demonstrated with some patents granted about new nanomanufacturing devices for future commercial applications, which also progressively helps in the development towards nanorobots with the use of embedded nanobioelectronics concepts.[51][52]
Productive nanosystems are "systems of nanosystems" which will be complex nanosystems that produce atomically precise parts for other nanosystems, not necessarily using novel nanoscale-emergent properties, but well-understood fundamentals of manufacturing. Because of the discrete (i.e. atomic) nature of matter and the possibility of exponential growth, this stage is seen as the basis of another industrial revolution. Mihail Roco, one of the architects of the US's National Nanotechnology Initiative, has proposed four states of nanotechnology that seem to parallel the technical progress of the Industrial Revolution, progressing from passive nanostructures to active nanodevices to complex nanomachines and ultimately to productive nanosystems.[53]
Due to the popularity and media exposure of the term nanotechnology, the words picotechnology and femtotechnology have been coined in analogy to it, although these are only used rarely and informally.
Dimensionality in nanomaterials
Nanomaterials can be classified in 0D, 1D, 2D and 3D nanomaterials. The dimensionality play a major role in determining the characteristic of nanomaterials including physical, chemical and biological characteristics. With the decrease in dimensionality, an increase in surface-to-volume ratio is observed. This indicate that smaller dimensional nanomaterials have higher surface area compared to 3D nanomaterials. Recently, two dimensional (2D) nanomaterials are extensively investigated for electronic, biomedical, drug delivery and biosensor applications.
The tip of a scanning probe can also be used to manipulate nanostructures (a process called positional assembly). Feature-oriented scanning methodology may be a promising way to implement these nanomanipulations in automatic mode.[54][55] However, this is still a slow process because of low scanning velocity of the microscope.
Another group of nanotechnological techniques include those used for fabrication of nanotubes and nanowires, those used in semiconductor fabrication such as deep ultraviolet lithography, electron beam lithography, focused ion beam machining, nanoimprint lithography, atomic layer deposition, and molecular vapor deposition, and further including molecular self-assembly techniques such as those employing di-block copolymers. The precursors of these techniques preceded the nanotech era, and are extensions in the development of scientific advancements rather than techniques which were devised with the sole purpose of creating nanotechnology and which were results of nanotechnology research.[56]
The top-down approach anticipates nanodevices that must be built piece by piece in stages, much as manufactured items are made. Scanning probe microscopy is an important technique both for characterization and synthesis of nanomaterials. Atomic force microscopes and scanning tunneling microscopes can be used to look at surfaces and to move atoms around. By designing different tips for these microscopes, they can be used for carving out structures on surfaces and to help guide self-assembling structures. By using, for example, feature-oriented scanning approach, atoms or molecules can be moved around on a surface with scanning probe microscopy techniques.[54][55] At present, it is expensive and time-consuming for mass production but very suitable for laboratory experimentation.
In contrast, bottom-up techniques build or grow larger structures atom by atom or molecule by molecule. These techniques include chemical synthesis, self-assembly and positional assembly. Dual polarisation interferometry is one tool suitable for characterisation of self assembled thin films. Another variation of the bottom-up approach is molecular beam epitaxy or MBE. Researchers at Bell Telephone Laboratories like John R. Arthur. Alfred Y. Cho, and Art C. Gossard developed and implemented MBE as a research tool in the late 1960s and 1970s. Samples made by MBE were key to the discovery of the fractional quantum Hall effect for which the 1998 Nobel Prize in Physics was awarded. MBE allows scientists to lay down atomically precise layers of atoms and, in the process, build up complex structures. Important for research on semiconductors, MBE is also widely used to make samples and devices for the newly emerging field of spintronics.
However, new therapeutic products, based on responsive nanomaterials, such as the ultradeformable, stress-sensitive Transfersome vesicles, are under development and already approved for human use in some countries.[57]
As of August 21, 2008, the Project on Emerging Nanotechnologies estimates that over 800 manufacturer-identified nanotech products are publicly available, with new ones hitting the market at a pace of 3–4 per week.[18] The project lists all of the products in a publicly accessible online database. Most applications are limited to the use of "firstgeneration" passive nanomaterials which includes titanium dioxide in sunscreen, cosmetics, surface coatings,[58] and some food products; Carbon allotropes used to produce gecko tape; silver in food packaging, clothing, disinfectants and household appliances; zinc oxide in sunscreens and cosmetics, surface coatings, paints and outdoor furniture varnishes; and cerium oxide as a fuel catalyst.[17]
Further applications allow tennis balls to last longer, golf balls to fly straighter, and even bowling balls to become more durable and have a harder surface. Trousers and socks have been infused with nanotechnology so that they will last longer and keep people cool in the summer. Bandages are being infused with silver nanoparticles to heal cuts faster.[59]Video game consoles and personal computers may become cheaper, faster, and contain more memory thanks to nanotechnology.[60] Also, to build structures for on chip computing with light, for example on chip optical quantum information processing, and picosecond transmission of information.[61]
Nanotechnology may have the ability to make existing medical applications cheaper and easier to use in places like the general practitioners' offices and at homes.[62] Cars are being manufactured using nanomaterials in such ways that car parts require fewer metals during manufacturing and less fuel to operate in the future.[63]
Nanoencapsulation is a technology involving the enclosure of active substances within carriers or particles of nanometer size. Typically, these carriers are nanoparticles that offer various advantages, such as enhanced bioavailability, controlled release, targeted delivery, and protection of the encapsulated substances. In the medical field, nanoencapsulation plays a significant role in drug delivery and therapeutic strategies. It facilitates more efficient drug administration, minimizing side effects, and increasing treatment effectiveness by encapsulating drugs within nanoparticles. Nanoencapsulation is particularly useful for improving the bioavailability of poorly water-soluble drugs, enabling controlled and sustained drug release, and supporting the development of targeted therapies. These features collectively contribute to advancements in medical treatments and patient care.[64][65]
Scientists are now turning to nanotechnology in an attempt to develop diesel engines with cleaner exhaust fumes. Platinum is currently used as the diesel engine catalyst in these engines. The catalyst is what cleans the exhaust fume particles. First, a reduction catalyst is employed to take nitrogen atoms from NOx molecules in order to free oxygen. Next the oxidation catalyst oxidizes the hydrocarbons and carbon monoxide to form carbon dioxide and water.[citation needed] Platinum is used in both the reduction and the oxidation catalysts.[66] Using platinum though, is inefficient in that it is expensive and unsustainable. Danish company InnovationsFonden invested DKK 15 million in a search for new catalyst substitutes using nanotechnology. The goal of the project, launched in the autumn of 2014, is to maximize surface area and minimize the amount of material required. Objects tend to minimize their surface energy; two drops of water, for example, will join to form one drop and decrease surface area. If the catalyst's surface area that is exposed to the exhaust fumes is maximized, efficiency of the catalyst is maximized. The team working on this project aims to create nanoparticles that will not merge. Every time the surface is optimized, material is saved. Thus, creating these nanoparticles will increase the effectiveness of the resulting diesel engine catalyst—in turn leading to cleaner exhaust fumes—and will decrease cost. If successful, the team hopes to reduce platinum use by 25%.[67]
Nanotechnology also has a prominent role in the fast developing field of Tissue Engineering. When designing scaffolds, researchers attempt to mimic the nanoscale features of a cell's microenvironment to direct its differentiation down a suitable lineage.[68] For example, when creating scaffolds to support the growth of bone, researchers may mimic osteoclast resorption pits.[69]
Researchers have successfully used DNA origami-based nanobots capable of carrying out logic functions to achieve targeted drug delivery in cockroaches. It is said that the computational power of these nanobots can be scaled up to that of a Commodore 64.[70]
An area of concern is the effect that industrial-scale manufacturing and use of nanomaterials would have on human health and the environment, as suggested by nanotoxicology research. For these reasons, some groups advocate that nanotechnology be regulated by governments. Others counter that overregulation would stifle scientific research and the development of beneficial innovations. Public health research agencies, such as the National Institute for Occupational Safety and Health are actively conducting research on potential health effects stemming from exposures to nanoparticles.[71][72]
Some nanoparticle products may have unintended consequences. Researchers have discovered that bacteriostatic silver nanoparticles used in socks to reduce foot odor are being released in the wash.[73] These particles are then flushed into the waste water stream and may destroy bacteria which are critical components of natural ecosystems, farms, and waste treatment processes.[74]
Public deliberations on risk perception in the US and UK carried out by the Center for Nanotechnology in Society found that participants were more positive about nanotechnologies for energy applications than for health applications, with health applications raising moral and ethical dilemmas such as cost and availability.[75]
Experts, including director of the Woodrow Wilson Center's Project on Emerging Nanotechnologies David Rejeski, have testified[76] that successful commercialization depends on adequate oversight, risk research strategy, and public engagement. Berkeley, California is currently the only city in the United States to regulate nanotechnology;[77] In 2008, Cambridge, Massachusetts considered enacting a similar law,[78] but ultimately rejected it.[79]
Nanofibers are used in several areas and in different products, in everything from aircraft wings to tennis rackets. Inhaling airborne nanoparticles and nanofibers may lead to a number of pulmonary diseases, e.g. fibrosis.[80] Researchers have found that when rats breathed in nanoparticles, the particles settled in the brain and lungs, which led to significant increases in biomarkers for inflammation and stress response[81] and that nanoparticles induce skin aging through oxidative stress in hairless mice.[82][83]
A two-year study at UCLA's School of Public Health found lab mice consuming nano-titanium dioxide showed DNA and chromosome damage to a degree "linked to all the big killers of man, namely cancer, heart disease, neurological disease and aging".[84]
A Nature Nanotechnology study suggests some forms of carbon nanotubes – a poster child for the "nanotechnology revolution" – could be as harmful as asbestos if inhaled in sufficient quantities. Anthony Seaton of the Institute of Occupational Medicine in Edinburgh, Scotland, who contributed to the article on carbon nanotubes said "We know that some of them probably have the potential to cause mesothelioma. So those sorts of materials need to be handled very carefully."[85] In the absence of specific regulation forthcoming from governments, Paull and Lyons (2008) have called for an exclusion of engineered nanoparticles in food.[86] A newspaper article reports that workers in a paint factory developed serious lung disease and nanoparticles were found in their lungs.[87][88][89][90]
Calls for tighter regulation of nanotechnology have occurred alongside a growing debate related to the human health and safety risks of nanotechnology.[91] There is significant debate about who is responsible for the regulation of nanotechnology. Some regulatory agencies currently cover some nanotechnology products and processes (to varying degrees) – by "bolting on" nanotechnology to existing regulations – there are clear gaps in these regimes.[92] Davies (2008) has proposed a regulatory road map describing steps to deal with these shortcomings.[93]
Stakeholders concerned by the lack of a regulatory framework to assess and control risks associated with the release of nanoparticles and nanotubes have drawn parallels with bovine spongiform encephalopathy ("mad cow" disease), thalidomide, genetically modified food,[94] nuclear energy, reproductive technologies, biotechnology, and asbestosis. Andrew Maynard, chief science advisor to the Woodrow Wilson Center's Project on Emerging Nanotechnologies, concludes that there is insufficient funding for human health and safety research, and as a result there is currently limited understanding of the human health and safety risks associated with nanotechnology.[95] As a result, some academics have called for stricter application of the precautionary principle, with delayed marketing approval, enhanced labelling and additional safety data development requirements in relation to certain forms of nanotechnology.[96]
The Royal Society report[15] identified a risk of nanoparticles or nanotubes being released during disposal, destruction and recycling, and recommended that "manufacturers of products that fall under extended producer responsibility regimes such as end-of-life regulations publish procedures outlining how these materials will be managed to minimize possible human and environmental exposure" (p. xiii).
The Center for Nanotechnology in Society has found that people respond to nanotechnologies differently, depending on application – with participants in public deliberations more positive about nanotechnologies for energy than health applications – suggesting that any public calls for nano regulations may differ by technology sector.[75]
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French composer Jean Maillard; portrait from Le Roy & Ballard's publications of his two volumes of motets, 1565 Jean Maillard (c. 1515 – after 1570) was a French composer of the Renaissance. While little is known with certainty about his life, he may have been associated with the French royal court, since he wrote at least one motet for them. Most likely he lived and worked in Paris, based on evidence of his print editions, which were prepared there. Since later in his career he set ve…
Lamennais. Porträt von L. D. Lancôme Félicité Robert de Lamennais (* 19. Juni 1782 in Saint-Malo; † 27. Februar 1854 in Paris) war ein französischer Priester, Philosoph und Verfasser politischer Schriften. Inhaltsverzeichnis 1 Leben 2 Werke (Auswahl) 3 Literatur 4 Weblinks 5 Einzelnachweise Leben Lamennais, Sohn eines geadelten Reeders, verlor seine Mutter mit fünf Jahren und wuchs bei einem Onkel auf. Sein älterer Bruder Jean-Marie (1780–1860) begründete die Ordensgemeinschaft …
Saudi Arabian order of merit This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed.Find sources: Order of King Abdulaziz – news · newspapers · books · scholar · JSTOR (March 2011) (Learn how and when to remove this template message) Order of King AbdulazizInsignia of the Order of Abdulaziz Al Saud(5th grade)Star of the Order of Ab…
Brazilian Lieutenant-Brigadier of the Brazilian Air Force Lieutenant-BrigadierRaul BotelhoChief of the Joint Staff of the Armed ForcesIn office15 January 2019 – 31 May 2021PresidentJair BolsonaroMinisterFernando Azevedo e SilvaPreceded byAdemir SobrinhoSucceeded byLaerte de Souza Santos Personal detailsBorn (1957-07-22) 22 July 1957 (age 66)São Paulo, São Paulo, BrazilAlma materBrazilian Air Force AcademyMilitary serviceAllegiance BrazilBranch/service Brazilian Air ForceYe…
Картина Беди Стєрншанца «Склодуви» є частиною колекції Художнього музею К. Х. Ренлунда в Кокколі. Склодув з Каїру Гýтництво — виготовлення виробів із скла, що відоме в Україні понад тисячу років. Точний час його виникнення не встановлено, але в скіфських похованнях уже
Опис файлу Опис Постер до фільму «Наше Різдво» Джерело R_xmas_poster.jpg (англ. вікі) Час створення 2001 Автор зображення Авторські права належать дистриб'ютору, видавцю фільму або художнику цього постера. Ліцензія див. нижче Обґрунтування добропорядного використання для стат
الانتخابات التشريعية السورية 2020 →2016 19 يوليو 2020 2024← جميع المقاعد 250 لمجلس الشعب السوريالمقاعد اللازمة للأغلبية 126 نسبة المشاركة 33,17%[1] الحزب الأول القائد بشار الأسد الحزب حزب البعث العربي الاشتراكي التحالف الجبهة الوطنية التقدمية (سوريا) آخر انتخاب 200 مق…
هذه المقالة يتيمة إذ تصل إليها مقالات أخرى قليلة جدًا. فضلًا، ساعد بإضافة وصلة إليها في مقالات متعلقة بها. (يونيو 2019) أنماري أوير معلومات شخصية الميلاد 10 يونيو 1913[1] نويمونستر الوفاة 7 فبراير 2002 (88 سنة) [1] برلين مواطنة ألمانيا الحياة العملية المهنة كاتِب…
2009 biographical sports drama film InvictusTheatrical release posterDirected byClint EastwoodScreenplay byAnthony PeckhamBased onPlaying the Enemy: Nelson Mandela and the Game that Made a Nation2008 bookby John CarlinProduced by Clint Eastwood Lori McCreary Robert Lorenz Mace Neufeld Starring Morgan Freeman Matt Damon CinematographyTom SternEdited by Joel Cox Gary D. Roach Music by Kyle Eastwood Michael Stevens ProductioncompaniesSpyglass Entertainment[1]Malpaso Productions[1]Re…
Komando Distrik Militer 1802/SorongNegara IndonesiaCabang TNI Angkatan DaratTipe unitKodimPeranSatuan TeritorialBagian dariKorem 181/PVTMakodimSorong, Papua Barat DayaPelindungTentara Nasional IndonesiaMotoWira Satya BhaktiBaret H I J A U MaskotKasuariSitus webkasuari18-tniad.mil.idTokohKomandanLetkol Cpn Andi Sigit Pamungkas, S,E., M.IP Komando Distrik Militer (Kodim) 1802/Sorong merupakan Kodim yang berada dibawah komando Korem 181/Praja Vira Tama. Kodim 1802/Sorong memiliki wil…
Institutional corruption in the country Political corruption Concepts Anti-corruption Bribery Cronyism Economics of corruption Electoral fraud Elite capture Influence peddling Kleptocracy Mafia state Nepotism Slush fund Simony Corruption by country Africa Angola Botswana Cameroon Chad Comoros Congo Egypt Equatorial Guinea Eritrea Ethiopia Ghana Guinea-Bissau Kenya Liberia Mauritius Morocco Nigeria Senegal Sierra Leone Somalia South Africa South Sudan Sudan Tanzania Tunisia Uganda Zambia Zimbabwe…
American politician William A. PrendergastBornWilliam Ambrose Prendergast(1867-05-25)May 25, 1867New York, New YorkDiedJune 20, 1954(1954-06-20) (aged 87)Lakeville, ConnecticutOccupation(s)Businessman, politicianPolitical partyRepublicanSpouseMary Agnes HallChildrenEleanor PrendergastWilliam A. Predergast, Jr.Thomas H. Prendergast William Ambrose Prendergast (May 25, 1867 – June 20, 1954) was an American businessman and politician from New York. William A. Prendergast, (on the left) and f…
American/Canadian television series HavenGenreSupernatural DramaCrimeFantasyHorrorMysterySci-FiThrillerBased onThe Colorado Kidby Stephen KingDeveloped by Sam Ernst Jim Dunn Starring Emily Rose Lucas Bryant Nicholas Campbell Eric Balfour Theme music composer Andre Fratto Leah Siegel ComposerShawn PierceCountry of origin United States Canada Original languageEnglishNo. of seasons5No. of episodes78 (list of episodes)ProductionExecutive producers Sam Ernst Jim Dunn David MacLeod John Morayniss Nore…
Calcium sorosilicate mineral TilleyiteTilleyite collected from Crestmore quarries, Riverside County, CaliforniaGeneralCategorySorosilicateFormula(repeating unit)Ca3[Si2O7]·2CaCO3IMA symbolTly[1]Strunz classification9.BE.82Crystal systemMonoclinicCrystal classPrismatic (2/m) (same H-M symbol)Space groupP21/bUnit cella = 15.108(3) Å b = 10.241(1) Å c = 7.579(1) Å β = 105.17(1)° Z = 4IdentificationColourColourless, whiteTwinningSimple twinning {100}, often lamellar; α:twin pl…
Person who uses skill and deception to win at poker or other card games Card shark redirects here. For other uses, see Card Shark (disambiguation). The Cardsharps (ca. 1594) by Caravaggio Le Tricheur à l'as de carreau [fr] (1635) by Georges de La Tour A card sharp (also card shark, sometimes hyphenated or spelled as a single word) is a person who uses skill and/or deception to win at poker or other card games. Sharp and shark spellings have varied over time and by region. The label…
جزء من سلسلة مقالات عنالسياسة في روما القديمة الفترات المملكة الرومانية 753 – 509 ق م الجمهورية الرومانية 509 – 27 ق م الإمبراطورية الرومانية 27 ق م – 476م عهد الزعامة الإمبراطورية الغربية عهد السيادة الإمبراطورية الشرقية الدستور الروماني دستور المملكة دستور الجمهورية دستور الإم…
Swedish author and journalist Cilla Naumann in 2012 Cilla Naumann (born 16 July 1960) is a Swedish author and journalist. Her first book, Vattenhjärta, came out in 1995. It won the Katapulpriset for Best debut of the Year.[1] Her next book was Dom, published in 2000.[2] Bibliography 1995 – Vattenhjärta 1996 – Väntan tillbaka 1998 – Vågorna Alma, vågorna 2000 – Dom 2002– Dem oss skyldiga äro 2004 – Fly 2006 – Värsta brorsan 2007 – Vad ser du nu 2009 – I ci…
Generalization of electrodynamics In theoretical physics, p-form electrodynamics is a generalization of Maxwell's theory of electromagnetism. Ordinary (via. one-form) Abelian electrodynamics We have a one-form A {\displaystyle \mathbf {A} } , a gauge symmetry A → A + d α , {\displaystyle \mathbf {A} \rightarrow \mathbf {A} +d\alpha ,} where α {\displaystyle \alpha } is any arbitrary fixed 0-form and d {\displaystyle d} is the exterior derivative, and a gauge-invariant vector…
United States historic placeBoreas Railroad Station SiteU.S. National Register of Historic Places LocationBoreas Pass Rd. northwest of Como, Colorado in the Pike National ForestArea19 acres (7.7 ha)Built1881Built byDenver, South Park & Pacific RailroadNRHP reference No.93001108[1]Added to NRHPOctober 28, 1993 The Boreas Railroad Station Site is a 19 acres (7.7 ha) site in Pike National Forest near Como, Colorado which was listed on the National Register of Histori…
Municipality of the Philippines in the province of AntiqueAnini-yMunicipalityMunicipality of Anini-yAnini-y Church FlagSealAnthem: Anini-y, Banwang Pinili (unofficial)Map of Antique with Anini-y highlightedOpenStreetMapAnini-yLocation in the PhilippinesCoordinates: 10°25′57″N 121°55′31″E / 10.432475°N 121.925286°E / 10.432475; 121.925286CountryPhilippinesRegionWestern VisayasProvinceAntiqueDistrict Lone districtBarangays23 (see Barangays)Government […
City in Delaware, United States City in Delaware, United StatesSeaford, DelawareCityHigh Street in SeafordEtymology: Seaford, East Sussex in EnglandLocation of Seaford in Sussex County, Delaware.SeafordLocation within the state of DelawareShow map of DelawareSeafordSeaford (the United States)Show map of the United StatesCoordinates: 38°38′28″N 75°36′40″W / 38.64111°N 75.61111°W / 38.64111; -75.61111Country United StatesState DelawareCounty SussexInco…
Word or phrase said to cause magical events This article is about words used in stage magic. For formulae used in ceremonial magic, see magical formula. For other uses, see Magic word (disambiguation).For magic words on Wikipedia, see Help:Magic words. Classic magic words Magic words are phrases used in fantasy fiction or by stage magicians. Frequently such words are presented as being part of a divine, adamic, or other secret or empowered language. Certain comic book heroes use magic words to a…
This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed.Find sources: Venda Sexy – news · newspapers · books · scholar · JSTOR (November 2016) (Learn how and when to remove this template message) Venda SexyPrison camp used during the Military dictatorship of ChileView of the former Venda SexyLocation of Venda Sexy in contemporary Ch…
Irish photographer Robert WelchBorn(1859-07-22)22 July 1859Strabane, County Tyrone, IrelandDied28 September 1936(1936-09-28) (aged 77)Londsale Street,[1] Belfast, County Antrim, Northern IrelandNationalityIrishKnown forPhotography Robert John Welch (22 July 1859 – 28 September 1936) was an Irish photographer interested in natural history, particularly mollusca. Welch, born in Strabane, County Tyrone, lived for a time in Enniskillen. He was the son of an accomplished Scottish …
South Korean machinery company For other uses, see Rotem (disambiguation). Hyundai Rotem CompanyHyundai Rotem Headquarters in UiwangNative name현대로템주식회사Romanized nameHyeondae rotem jusikoesaFormerlyKorea Rolling Stock Corporation (1999–2001)Rotem (2002–2007)Hyundai Rotem (2007–present)TypePublicTraded asKRX: 064350IndustryRailwaysDefenseFactoriesPredecessorsRolling stock divisions ofHyundai Precision & IndustryDaewoo Heavy IndustriesHanjin Heavy IndustriesFou…
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