NOM1

NOM1
Identifiers
Aliases	NOM1, C7orf3, PPP1R113, SGD1, nucleolar protein with MIF4G domain 1
External IDs	OMIM: 611269; MGI: 1861749; HomoloGene: 39776; GeneCards: NOM1; OMA:NOM1 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q36.3 Start 156,949,712 bp[1] End 156,973,176 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 B1|5 15.0 cM Start 29,639,662 bp[2] End 29,662,841 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pancreatic epithelial cell visceral pleura germinal epithelium parietal pleura gingival epithelium body of pancreas skin of abdomen epithelium of colon skin of leg gonad Top expressed in spermatocyte epiblast ovary ventricular zone placenta spermatid liver ganglionic eminence tail of embryo thymus More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding RNA binding Cellular component nucleolus nucleus Biological process neurogenesis ribosomal small subunit biogenesis hair follicle maturation biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64434 433864 Ensembl ENSG00000146909 ENSMUSG00000001569 UniProt Q5C9Z4 Q3UFM5 RefSeq (mRNA) NM_138400 NM_001353366 NM_001033457 RefSeq (protein) NP_612409 NP_001340295 NP_001028629 Location (UCSC) Chr 7: 156.95 – 156.97 Mb Chr 5: 29.64 – 29.66 Mb PubMed search [3] [4]
Wikidata
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Nucleolar protein with MIF4G domain 1 is a protein that in humans is encoded by the NOM1 gene.^[5]

Proteins that contain MIF4G (middle of eIF4G (MIM 600495)) and/or MA3 domains, such as NOM1, function in protein translation. These domains include binding sites for members of the EIF4A family of ATP-dependent DEAD box RNA helicases.^[6][5]

References

1. GRCh38: Ensembl release 89: ENSG00000146909 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000001569 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Nucleolar protein with MIF4G domain 1". Retrieved 2011-09-27.
6. Simmons HM, Ruis BL, Kapoor M, Hudacek AW, Conklin KF (February 2005). "Identification of NOM1, a nucleolar, eIF4A binding protein encoded within the chromosome 7q36 breakpoint region targeted in cases of pediatric acute myeloid leukemia". Gene. 347 (1): 137–145. doi:10.1016/j.gene.2004.12.027. PMID 15715967.

Further reading

• Heus HC, Hing A, van Baren MJ, Joosse M, Breedveld GJ, Wang JC, et al. (May 1999). "A physical and transcriptional map of the preaxial polydactyly locus on chromosome 7q36". Genomics. 57 (3): 342–351. doi:10.1006/geno.1999.5796. PMID 10329000.
• Simmons HM, Ruis BL, Kapoor M, Hudacek AW, Conklin KF (February 2005). "Identification of NOM1, a nucleolar, eIF4A binding protein encoded within the chromosome 7q36 breakpoint region targeted in cases of pediatric acute myeloid leukemia". Gene. 347 (1): 137–145. doi:10.1016/j.gene.2004.12.027. PMID 15715967.
• Gunawardena SR, Ruis BL, Meyer JA, Kapoor M, Conklin KF (January 2008). "NOM1 targets protein phosphatase I to the nucleolus". The Journal of Biological Chemistry. 283 (1): 398–404. doi:10.1074/jbc.M706708200. PMID 17965019.
• Alexandrov A, Colognori D, Steitz JA (May 2011). "Human eIF4AIII interacts with an eIF4G-like partner, NOM1, revealing an evolutionarily conserved function outside the exon junction complex". Genes & Development. 25 (10): 1078–1090. doi:10.1101/gad.2045411. PMC 3093123. PMID 21576267.