A post office called Mount Holly was established in 1853, and remained in operation until it was discontinued in 1990.[2] Mount Holly was originally the name of a nearby plantation.[3]
The historic Medway Plantation (c. 1694) is located within the village and possibly the oldest house in South Carolina.[4] In the 19th century, the Mount Holly Mining and Manufacturing Company was active in the village.
^"Medway, Berkeley County (off U.S. Hwy. 52, Mount Holly vicinity)". National Register Properties in South Carolina. South Carolina Department of Archives and History. Retrieved 8 April 2009.