The stadium's original capacity was 15,000 but it was expanded. Half of the project was completed by December 2006 and the stadium hosted the 18th Arabian Gulf Cup the next month. The UAE won the tournament in the stadium which held 24,000 spectators. The stadium was expanded again for the 2019 AFC Asian Cup.
The Mohammed bin Zayed Stadium hosted seven games of the 2019 AFC Asian Cup, including a round of 16 match, a quarter-final match and a semi-final match.