The village of Mirkovo bears traces of ancient settlements. In the "Mogila" area, 3.5 km south of Mirkovo, remains of a Neolithic settlement have been discovered. In the areas of "Deninata Plocha," "Ortova," "Usta," "Yalamovoto Tepe," and "Hriskovata Plocha," remnants of Thracian settlements have been found. The "Aramudere" area within the village's territory conceals a tomb from Roman times. Near the village, in the "Taushanitsa" locality, an early Christian sanctuary is located. Valuable medieval monuments have also been uncovered near Mirkovo, including the church of "St. George" from the 12th-13th century, as well as remnants of a fortress guarding the pass to Etropole in the "Gradishte" area.
The earliest mentions of the village of Mirkovo (or Mirkova) are found in Ottoman records from 1430 and 1751.
In 1825, during the Bulgarian Revival, a kiln school was established in the village. Residents of Mirkovo participated in the squads of Panayot Hitov, Hristo Botev, and Georgi Benkovski. Thirty-eight people from Mirkovo joined the Russo-Turkish Liberation War.
In 1878, Ivan Radov Maslev opened the first brewery in Bulgaria in the village, and in 1883, the factory was relocated to Sofia on "Solni Pazar."
In 1884, the "Mirkovo Scientific Society 'Iskra'" was founded, and in 1908, the "Prosveta" community center was established. In 1909, they merged into the "Hristo Botev" community center.
In 1890, Todor Vlaykov and Todor Yonchev founded the first Bulgarian cooperative in Mirkovo – the Mirkovo Credit, Savings, and Agricultural Society "Oralo"; in 1914, the "Pchela" credit cooperative was established as the successor to "Oralo."
