She completed undergraduate studies in 1999 at The University of Sydney,[1] with honours and a double major of Molecular Biology and Genetics.[2] As part of her doctoral research at the same institution under the supervision of Associate Professor Emma Whitelaw, she designed a sensitised mutagenesis screen to find new epigenetic modifiers in mice, for which she was awarded the Genetics Society of Australia DG Catcheside prize for the best PhD in genetics. She moved to Melbourne at the end of 2005 to accept a Peter Doherty post-doctoral fellowship in Doug Hilton's[3] lab from 2005 to 2009, before becoming laboratory head in January 2010.[4]
Research interests
Blewitt's lab focuses on molecular mechanisms behind epigenetic control of gene expression. Her lab has worked on one of the mouse mutants identified in the mutagenesis screen, identifying a critical role for the protein Smchd1 in X inactivation in cancer.[5] Other research activities include the study of the roles of polycomb-group proteins in hematopoieticstem cell function.
Blewitt ME, Gendrel A-V, Pang Z, Sparrow DB, Whitelaw N, Craig J, Apedaile A, Hilton DJ, Dunwoodie SL, Brockdorff N, Kay GK and Whitelaw E (2008) SmcHD1, a protein containing a structural maintenance of chromosomes hinge domain, has a critical role in X inactivation. Nat Genet May; 40(5):663-9. PMID18425126
Majewski IJ, Blewitt M, deGraaf C, McManus E, Bahlo M, Hyland C, Smyth GK, Corbin J, Metcalf D, Alexander WS, and Hilton DJ (2008) Polycomb repressive complex 2 (PRC2) restricts hematopoietic stem cell identity. PLoS Biology 15 Apr; 6(4):e93. PMID18416604
Blewitt ME, Vickaryous NK, Hemley SJ, Ashe A, Bruxner TJ, Preis JI, Arkell R and Whitelaw E (2005) An ENU screen for genes involved in variegation in the mouse. Proc Natl Acad Sci U S A 102(21): 7629–7634. PMID15890782
Ashe A, Morgan DK, Whitelaw NC, Bruxner TJ, Vickaryous NK, Cox LL, Butterfield NC, Wicking C, Blewitt ME, Wilkins S, Anderson G, Cox TX and Whitelaw E. (2008) A genome-wide screen for modifiers of transgene variegation identifies genes with critical roles in development. Genome Biol Vol 9 (12) R182 PMID19099580
Chong S, Vickaryous N, Ashe A, Zamudio N, Youngson N, Hemley S, Stopka T, Skoultchi A, Matthews J, Scott H, de Kretser D, O’Bryan M, Blewitt M and Whitelaw E (2007) Modifiers of epigenetic reprogramming show paternal effects in the mouse. Nat Genet 2007 May;39(5):614-22. Epub 2007 Apr 22. PMID17450140
Blewitt ME, Vickaryous NK, Paldi A Koseki H and Whitelaw E (2006) Dynamic reprogramming of DNA methylation at an epigenetically sensitive allele in mice. PLoS Genetics April 2(4) e49. PMID16604157
Rakyan VK, Chong S, Champ ME, Cuthbert PC, Morgan HD, Luu KVK and Whitelaw E (2003) Transgenerational inheritance of epigenetic states at the murine AxinFu allele occurs following maternal and paternal transmission. Proc Natl Acad Sci U S A 100(5): 2538–43 PMID12601169
