The river was explored in 1805 by the Lewis and Clark Expedition. Some of the men on the expedition mistook it for the main branch of the Missouri until their subsequent discovery of the Great Falls of the Missouri near Great Falls, Montana. The river was named by Meriwether Lewis after his cousin, Maria Wood. Lewis led a small detachment of men to further explore the Marias River on the Expedition's return trip in 1806 to determine if the river ventured north above the Canada border, and he killed a young Blackfeet warrior trying to steal horses and a gun from the small detachment.