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Mannitol-1-phosphate 5-dehydrogenase

mannitol-1-phosphate 5-dehydrogenase
Identifiers
EC no.1.1.1.17
CAS no.9028-24-4
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BRENDABRENDA entry
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MetaCycmetabolic pathway
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In enzymology, a mannitol-1-phosphate 5-dehydrogenase (EC 1.1.1.17) is an enzyme that catalyzes the chemical reaction

D-mannitol 1-phosphate + NAD+ D-fructose 6-phosphate + NADH + H+

Thus, the two substrates of this enzyme are D-mannitol 1-phosphate and NAD+, whereas its 3 products are fructose 6-phosphate, NADH and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is D-mannitol-1-phosphate:NAD+ 2-oxidoreductase. Other names in common use include hexose reductase, mannitol 1-phosphate dehydrogenase, D-mannitol-1-phosphate dehydrogenase, and fructose 6-phosphate reductase. This enzyme participates in fructose and mannose metabolism.

See also

References

  • Marmur J, Hotchkiss RD (1955). "Mannitol metabolism, a transferable property of pneumococcus". J. Biol. Chem. 214 (1): 383–96. PMID 14367396.
  • Wolfe JB; Kaplan NO (1955). Wolff, Johnb; Kaplan, Nathano (eds.). "Hexose phosphate and hexose reductase. A. D-Mannitol-1-phosphate dehydrogenase from E. coli". Methods Enzymol. 1: 346–348. doi:10.1016/0076-6879(55)01050-1.
  • Wolfe JB; Kaplan NO (1956). "D-Mannitol 1-phosphate dehydrogenase from Escherichia coli". J. Biol. Chem. 218: 849–869. PMID 13295236.


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