The serial was created by Alan Grant and John Wagner, who scripted the early story arcs. The strip was subsequently written by Grant using the pseudonym "Keith Law",[1] and later by Scott Goodall.
The early adventures, like most of the serials published in Eagle at the time, were fumetti: illustrated by black-and-white photographs using actors, with text boxes and speech balloons superimposed. The photography for Manix was by Sven Arnstein. When Eagle ceased to publish fumettis and moved to a traditionally illustrated format in 1983, the art for the Manix strip was provided by Manuel Carmona.