In 1978, Seraj and her husband were put in prison by the Communist Party of Afghanistan and later that year declared persona non grata.[3] She then left for the United States,[1] at least initially New York City,[4] and lived there in exile for some 26 years, before returning to Afghanistan in 2003.[5][6][7] Following her return, she co-founded a number of organizations to address corruption and women and children's rights issues. Most notably as a member of the non-profit Afghan Women's Network, she has dedicated her cause to championing children's health, battling corruption and empowering victims of domestic violence. She is the creator and announcer of a radio program for women by the name of “Our Beloved Afghanistan by Mahbouba Seraj” which has been broadcast all over Afghanistan. She has also advocated for women to be part of the political discourse, through a National Action Plan, promoted by the UN.
When the Taliban returned to power in August 2021, Seraj refused to flee the country, deciding to remain in Kabul to continue to work with women and children.[8][9] In September 2021, she was included in the Time 100, Time's annual list of the 100 most influential people in the world.[10]
She has launched many campaigns both inside and outside Afghanistan to end the hatred of Iranians towards Afghans.[11]