MINK1

MINK1
Identifiers
Aliases	MINK1, B55, MAP4K6, MINK, YSK2, ZC3, hMINK, hMINKbeta, misshapen like kinase 1
External IDs	OMIM: 609426; MGI: 1355329; HomoloGene: 56762; GeneCards: MINK1; OMA:MINK1 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17p13.2 Start 4,833,340 bp[1] End 4,898,061 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B3 Start 70,453,707 bp[2] End 70,505,309 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Region I of hippocampus proper skin of leg skin of abdomen right hemisphere of cerebellum dorsal motor nucleus of vagus nerve nipple olfactory bulb inferior ganglion of vagus nerve ventral tegmental area mucosa of ileum Top expressed in visual cortex superior frontal gyrus primary visual cortex dentate gyrus of hippocampal formation granule cell neural layer of retina interventricular septum piriform cortex lip cerebellar cortex subiculum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity protein kinase activity nucleotide binding kinase activity protein serine/threonine kinase activity protein binding ATP binding MAP kinase kinase kinase kinase activity Cellular component cytoplasm cytosol postsynaptic membrane Golgi apparatus cell projection postsynaptic density membrane plasma membrane synapse cell junction axon dendrite extracellular exosome Biological process actin cytoskeleton reorganization regulation of cell migration intracellular signal transduction microvillus assembly dendrite morphogenesis phosphorylation response to stress positive regulation of JNK cascade regulation of cell-matrix adhesion regulation of AMPA receptor activity multicellular organism development protein phosphorylation JNK cascade regulation of cell-cell adhesion protein autophosphorylation chemical synaptic transmission regulation of mitotic cell cycle regulation of apoptotic process neuron projection morphogenesis MAPK cascade signal transduction stress-activated protein kinase signaling cascade activation of protein kinase activity positive regulation of p38MAPK cascade Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 50488 50932 Ensembl ENSG00000141503 ENSMUSG00000020827 UniProt Q8N4C8 Q9JM52 RefSeq (mRNA) NM_001024937 NM_015716 NM_153827 NM_170663 NM_001321236 NM_001045959 NM_001045964 NM_016713 NM_176893 RefSeq (protein) NP_001020108 NP_001308165 NP_056531 NP_722549 NP_733763 NP_001039424 NP_001039429 NP_057922 NP_795712 NP_001390484 NP_001390485 NP_001390486 Location (UCSC) Chr 17: 4.83 – 4.9 Mb Chr 11: 70.45 – 70.51 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Misshapen-like kinase 1 is an enzyme that in humans is encoded by the MINK1 gene.^[5][6][7]

Function

Misshapen-like kinase 1 is a serine/threonine kinase belonging to the germinal center kinase (GCK) family. The protein is structurally similar to the kinases that are related to NIK and may belong to a distinct subfamily of NIK-related kinases within the GCK family. Studies of the mouse homolog indicate an up-regulation of expression in the course of postnatal mouse cerebral development and activation of the cJun N-terminal kinase (JNK) and the p38 pathways. Alternative splicing occurs at this locus and four transcript variants encoding distinct isoforms have been identified.^[7]

Interactions

MINK1 has been shown to interact with NCK1.^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000141503 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020827 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Dan I, Watanabe NM, Kobayashi T, Yamashita-Suzuki K, Fukagaya Y, Kajikawa E, Kimura WK, Nakashima TM, Matsumoto K, Ninomiya-Tsuji J, Kusumi A (Mar 2000). "Molecular cloning of MINK, a novel member of mammalian GCK family kinases, which is up-regulated during postnatal mouse cerebral development". FEBS Letters. 469 (1): 19–23. doi:10.1016/S0014-5793(00)01247-3. PMID 10708748. S2CID 39793431.
6. Dan I, Watanabe NM, Kajikawa E, Ishida T, Pandey A, Kusumi A (Jul 2002). "Overlapping of MINK and CHRNE gene loci in the course of mammalian evolution". Nucleic Acids Research. 30 (13): 2906–10. doi:10.1093/nar/gkf407. PMC 117062. PMID 12087176.
7. "Entrez Gene: MINK1 misshapen-like kinase 1 (zebrafish)".
8. Hu Y, Leo C, Yu S, Huang BC, Wang H, Shen M, Luo Y, Daniel-Issakani S, Payan DG, Xu X (Dec 2004). "Identification and functional characterization of a novel human misshapen/Nck interacting kinase-related kinase, hMINK beta". The Journal of Biological Chemistry. 279 (52): 54387–97. doi:10.1074/jbc.M404497200. PMID 15469942.

Further reading

• Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Wistow G, Bernstein SL, Wyatt MK, Fariss RN, Behal A, Touchman JW, Bouffard G, Smith D, Peterson K (Jun 2002). "Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants". Molecular Vision. 8: 205–20. PMID 12107410.
• Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J (May 2003). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nature Biotechnology. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
• Campdelacreu J, Ezquerra M, Muñoz E, Oliva R, Tolosa E (Apr 2003). "Mutational study of the nuclear factor kappa B inducing kinase gene in patients with progressive supranuclear palsy". Neuroscience Letters. 340 (2): 158–60. doi:10.1016/S0304-3940(03)00105-8. PMID 12668260. S2CID 45355312.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (Aug 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Hu Y, Leo C, Yu S, Huang BC, Wang H, Shen M, Luo Y, Daniel-Issakani S, Payan DG, Xu X (Dec 2004). "Identification and functional characterization of a novel human misshapen/Nck interacting kinase-related kinase, hMINK beta". The Journal of Biological Chemistry. 279 (52): 54387–97. doi:10.1074/jbc.M404497200. PMID 15469942.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.