Born in Genoa,[2] Lipani joined the eponymous team's youth sector at the age of seven.[3] Having come through the club's youth ranks, he started playing for the under-19 squad during the 2021–22 season.[2][4]
Since the start of 2022–23 season, the midfielder started training with the first team, under head coach Alexander Blessin, before being regularly included in senior match-day squads by new manager Alberto Gilardino.[2][4] In December 2022, he renewed his professional contract with Genoa, with the length remaining undisclosed.[5]
On 25 February 2023, Lipani made his professional debut, coming on as a substitute for Milan Badelj at the 85th minute of a Serie B match against SPAL: in the same occasion, he served an assist for Eddie Salcedo, whose goal settled up the game's final score for a 3–0 win.[4][6][7] At the end of the campaign, he was involved in a double promotion, as Genoa's first team returned to Serie A after just one year,[8] while the Primavera squad gained automatic promotion back to the Campionato Primavera 1.[8][9]
On 8 August 2023, Lipani joined fellow Serie A club Sassuolo on a permanent deal,[10][11] for a reported fee of eight million euros, plus add-ons.[3][12] On 2 November, he made his debut for the club, coming on for Uroš Račić in the first half of extra-time of a Coppa Italia match against Spezia,[13][14] which ended in a 5–4 win on penalties.[14] On 3 January 2024, he made his first start for the Neroverdi in a 3–1 cup defeat to Atalanta.[13][15]
In May 2022, he was included in the Italian squad that took part in the UEFA European Under-17 Championship in Israel:[21] during the tournament, he scored a goal,[18] as the Azzurrini were eventually eliminated by the Netherlands (2–1) in the quarter-finals.[18]
Lipani is a right-footed holding midfielder,[2][4][6] who excels in winning the ball during the defensive phase, as well as creating chances for his team-mates, thanks to his technical skills.[2][4] Despite mainly playing in a defensive role, he has also been regarded for his goal contributions, thanks to his shooting abilities.[2][4]