Semedo played all of his youth football at Benfica, signing a youth contract with the club in 2018, as an under-17.[1]
Having made his way through the club's under-18 and under-19 during the following season—with an average of more than one goal per game—the young footballer signed his first professional contract with As Águias in August 2020.[2][3]
At that time he was also playing a major role in the Youth League, where the Benfica under-19 topped their group against Dynamo Kyiv, Barcelona and Bayern Munich, scoring a goal against the latter during a 2–0 away win in November 2021[8][9] and most notably during their last pool game, a 1–0 home win against the Ukrainian that earned them the top spot.[10][11]
Born in Portugal, Semedo is of Cape Verdean descent.[19] He was selected with Portugal under-16 during the 2019–20 season,[2][3] he later played with the under-19 in September 2021.[20]