The program participated in the first interracial American basketball game played south of the Mason–Dixon line at Hurt Gymnasium on February 12, 1952, a 65–63 win over Morgan State.[2]
Upon moving up from Division II in 1981, Loyola was an original member of the ECAC Metro Conference which changed its name to the Northeast Conference (NEC) on August 1, 1988.[3] During its eight seasons in the circuit, the Greyhounds never won the championship and had no appearances in either the NCAA or National Invitation Tournaments. The only player in the program's Division I history to have reached the National Basketball Association (NBA) is Mike Morrison, a four-year letterman from 1985 to 1989. An All-Conference First Team as a junior and senior, he was selected by the Phoenix Suns in the second round (51st overall) of the 1989 NBA draft. He was eventually named to the NEC 25th Anniversary All-Time Team in January 2006. Mark Amatucci was also honored as the circuit's Jim Phelan Coach of the Year in 1983–84.[4]
G.G. Smith, an assistant coach under Patsos for six seasons, was promoted to lead the Greyhounds into the Patriot League on April 12, 2013.[8] He announced his resignation on March 8, 2018 after five seasons in which the team posted 56–98 and 35–55 records overall and in the conference respectively.[9]
Tavaras Hardy, an assistant coach on Josh Pastner's staff at Georgia Tech for two years, was appointed as Smith's successor 20 days later on March 28.[10] His third campaign at Loyola ended with the Greyhounds advancing to its first Patriot League Championship Game in an 85–72 loss at Colgate on March 14, 2021 despite entering the tournament as the No. 9 seed.[11][12]
National champion
Postseason invitational champion
Conference regular season champion
Conference regular season and conference tournament champion
Division regular season champion
Division regular season and conference tournament champion
Conference tournament champion
Due to the COVID-19 pandemic, the Patriot League for the 2020–21 season was temporarily divided into three regional mini-conferences based on geography. Each team played a 16-game regular-season schedule which included four matches against each regional opponent.[14] As usual, listed standings position reflected by conference tournament seed.[15]