George Lloyd Spencer (March 27, 1893 – January 14, 1981) was an American politician from Arkansas. A member of the Democratic Party, he represented the state in the United States Senate from 1941 to 1943.
Spencer was appointed to the United States Senate on April 1, 1941, to finish the unexpired term of Senator Joseph Taylor Robinson. He served until January 3, 1943, and did not stand for election, preferring instead to return to the Navy for World War II service.